血清内皮细胞特异性分子—1与冠状动脉病变相关性研究(1)
摘要：目的 内皮细胞特异性分子-1是近年来发现的新型内皮功能紊乱生物标记物，内皮功能紊乱在冠心病发病过程中起了重要作用，本研究探讨冠心病患者入院血清ESM-1表达水平及与冠状动脉病变及其严重程度的关系。方法 对130例行冠状动脉造影检查患者，按造影结果分为冠心病组(70例)和对照组(非冠心病组，60例)，对所有入组患者进行血清ESM-1检测。比较两组患者血清ESM-1表达水平，同时，对冠心病组中将不同亚组患者的血清ESM-1水平进一步比较。结果 与对照组比较，冠心病组ESM-1水平较高[(1.31±0.72) ng/ml vs (1.09±0.14) ng/ml， P<0.05]、冠心病亚组中，多支血管病变者血清ESM-1水平明显高于单支血管病变组，差异有统计学意义(P<0.05)。结论 冠心病患者血清ESM-1水平高于对照组，ESM-1可能是冠心病患者内皮功能紊乱新型生物标记物，其表达水平且随血管病变程度加重而增高。
关键词：冠心病；内皮细胞特异性分子-1；生物标记物
, http://www.100md.com
中图分类号：R542.22 文献标识码：A 文章编号：1006-1959(2017)25-0179-02
Abstract：Objective Endothelial cell-specific molecule-1 is a new biomarker of endothelial dysfunction found in recent years.Endothelial dysfunction plays an important role in the pathogenesis of coronary heart disease.This study was to investigate the relationship between serum ESM-1 expression in patients with coronary heart disease and the severity of coronary artery disease.Methods 130 patients undergoing coronary angiography were divided into coronary heart disease group(70 cases)and control group(non-coronary heart disease group，60 cases)according to the results of angiography.Serum ESM-1 was detected in all patients.Serum ESM-1 levels were compared between the two groups，meanwhile，serum ESM-1 levels in different subgroups were further compared in CHD group.Results Compared with the control group，the ESM-1 level in CHD group was significantly higher than that in the control group[(1.31±0.72)ng/mL vs(1.09±0.14)ng/mL，P<0.05]，In the coronary heart disease subgroup，the level of ESM-1 in the multivessel disease group was significantly higher than that in the single vessel disease group(P<0.05).Conclusion The level of serum ESM-1 in patients with coronary heart disease is higher than that in the control group.ESM-1 may be a new biomarker of endothelial dysfunction in patients with coronary heart disease.The level of ESM-1 expression is increased with the severity of vascular disease.
, 百拇医药
Key words：Coronary heart disease；Endothelial cell-specific molecule-1；Biomarker
隨着社会的进步，人们生活方式改变，心血管疾病已经成为全球主要死亡原因。其中动脉粥样硬化性疾病呈现出上升的趋势[1]。内皮功能紊乱是冠状动脉粥样硬化性心脏病发病的始动环节并贯穿于冠心病发病整个过程。冠心病与内皮功能指标的研究为当前研究热点之一，内皮细胞特异性分子-1(Endothelial cell-specific molecule-1，ESM-1)，主要由血管内皮细胞分泌，可能是血管内皮细胞功能紊乱的生物标记物[2]。然而，关于ESM-1与冠心病患者冠状动脉病变的临床研究国内鲜见文献报道。本研究探讨冠心病与ESM-1水平之间的关系，从而对冠状动脉病变临床意义进行评估，为临床诊断治疗提供实验室依据。
1资料与方法
1.1一般资料
选择2015年1月～2016年7月于本院住院行冠状动脉造影并被确诊为冠心病的患者70例为冠心病组，其中男性40例，女性30例，平均年龄(63.67±12.07)岁；另选取60例行冠状动脉造影检结果正常者为对照组，其中男性36例，女性24例，平均年龄(60.66±7.59)岁。, http://www.100md.com(吴佳健 邱崇荣)
关键词：冠心病；内皮细胞特异性分子-1；生物标记物
, http://www.100md.com
中图分类号：R542.22 文献标识码：A 文章编号：1006-1959(2017)25-0179-02
Abstract：Objective Endothelial cell-specific molecule-1 is a new biomarker of endothelial dysfunction found in recent years.Endothelial dysfunction plays an important role in the pathogenesis of coronary heart disease.This study was to investigate the relationship between serum ESM-1 expression in patients with coronary heart disease and the severity of coronary artery disease.Methods 130 patients undergoing coronary angiography were divided into coronary heart disease group(70 cases)and control group(non-coronary heart disease group，60 cases)according to the results of angiography.Serum ESM-1 was detected in all patients.Serum ESM-1 levels were compared between the two groups，meanwhile，serum ESM-1 levels in different subgroups were further compared in CHD group.Results Compared with the control group，the ESM-1 level in CHD group was significantly higher than that in the control group[(1.31±0.72)ng/mL vs(1.09±0.14)ng/mL，P<0.05]，In the coronary heart disease subgroup，the level of ESM-1 in the multivessel disease group was significantly higher than that in the single vessel disease group(P<0.05).Conclusion The level of serum ESM-1 in patients with coronary heart disease is higher than that in the control group.ESM-1 may be a new biomarker of endothelial dysfunction in patients with coronary heart disease.The level of ESM-1 expression is increased with the severity of vascular disease.
, 百拇医药
Key words：Coronary heart disease；Endothelial cell-specific molecule-1；Biomarker
隨着社会的进步，人们生活方式改变，心血管疾病已经成为全球主要死亡原因。其中动脉粥样硬化性疾病呈现出上升的趋势[1]。内皮功能紊乱是冠状动脉粥样硬化性心脏病发病的始动环节并贯穿于冠心病发病整个过程。冠心病与内皮功能指标的研究为当前研究热点之一，内皮细胞特异性分子-1(Endothelial cell-specific molecule-1，ESM-1)，主要由血管内皮细胞分泌，可能是血管内皮细胞功能紊乱的生物标记物[2]。然而，关于ESM-1与冠心病患者冠状动脉病变的临床研究国内鲜见文献报道。本研究探讨冠心病与ESM-1水平之间的关系，从而对冠状动脉病变临床意义进行评估，为临床诊断治疗提供实验室依据。
1资料与方法
1.1一般资料
选择2015年1月～2016年7月于本院住院行冠状动脉造影并被确诊为冠心病的患者70例为冠心病组，其中男性40例，女性30例，平均年龄(63.67±12.07)岁；另选取60例行冠状动脉造影检结果正常者为对照组，其中男性36例，女性24例，平均年龄(60.66±7.59)岁。, http://www.100md.com(吴佳健 邱崇荣)
参见：首页 > 医疗版 > 疾病专题 > 心血管科 > 冠状动脉病