磷酸肌酸钠注射液治疗新生儿窒息后心肌损伤的效果研究(1)
摘 要：目的 分析新生儿窒息后心肌损伤应用磷酸肌酸钠治疗临床效果。方法 本实验共选取窒息后心肌损伤患儿52例，按照随机法将其分成研究组和对照组，研究组患者应用磷酸肌酸钠注射液治疗，对照组患者应用常规方案治疗。结果 研究组患者临床治疗总有效率96.15%和左心室射血分数(0.65±0.08)%和左心室短轴缩短率(0.49±0.06)%均明显高于对照组临床治疗总有效率61.54%和左心室射血分数(0.30±0.01)%和左心室短轴缩短率(0.16±0.05)%；同时研究组患者肌酸激酶同工酶(21.4±11.0)U/L和肌钙蛋白I(0.03±0.01)ng/ml均明显低于对照组患者酸激酶同工酶(51.5±11.5)U/L和肌钙蛋白I(0.12±0.03)ng/ml(P<0.05)，该组患儿临床效果更好。结论 窒息后心肌损伤患儿在临床治疗中应用磷酸肌酸钠效果更好，用药后能够有效改善患儿心功能情况，改善心肌损伤，促进其身体恢复，在临床中应用具有重要意义。
关键词：新生儿窒息后心肌损伤；常规方案；磷酸肌酸钠
, http://www.100md.com
中图分类号：R722.12 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.01.052
文章编号：1006-1959(2018)01-0136-02
Effect of Sodium Phosphocreatine Injection in the Treatment of Myocardial Injury after Asphyxia Neonatorum
ZHAO Hua1，HUANG Guang-ju2
(Department of Pediatrics1，Department of surgery2，People's Hospital of Xingshan Province，Yichang 443700，Hubei，China)
, 百拇医药
Abstract：Objective To analyze the clinical effect of sodium creatine phosphate in neonatal asphyxia after myocardial injury.Methods In this study， 52 children with myocardial injury after asphyxia were randomly divided into study group and control group. Patients in study group were treated with sodium creatine phosphate injection and patients in control group were treated with conventional regimen. Results The clinical treatment of patients with total efficiency of 96.15% and left ventricular ejection fraction(0.65±0.08)%and left ventricular fractional shortening(0.49±0.06)%were significantly higher than the control group total effective rate 61.54% and left ventricular ejection fraction (0.30 ±0.01)%and left ventricular fractional shortening(0.16±0.05)%；At the same time， patients in the study group，creatine kinase MB(21.4±11.0)U/L and troponin I(0.03±0.01)ng/ml were significantly lower than the control group of patients with acid kinase isoenzyme(51.5±11.5)U/L and troponin I (0.12 ±0.03)ng/ml(P<0.05)，the group of children with better clinical effect.Conclusion The effect of creatine phosphate sodium is better in the treatment of myocardial injury after asphyxia.It can effectively improve the cardiac function，improve myocardial injury and promote the recovery of the body，and is of great significance in clinical application.
, 百拇医药
Key words：Myocardial injury after neonatal asphyxia；Routine regimen；Sodium phosphocreatine
根据临床实践发现[1]，新生儿在患病过程中容易出现窒息情况，患儿心肌缺血、供血异常，导致其肌酸激酶同工酶指标升高，诱发心肌损伤、威胁生命安全。窒息后心肌损伤最常见的表现有心律失常、心源性休克等[2]。本实验共选取2015年10月～2017年5月窒息后心肌损伤患儿52例，对其中26例患儿应用磷酸肌酸钠治疗，效果较好，现报道如下。
1 資料与方法
1.1 一般资料 将本院2015年10月～2017年5月收治的心肌损伤患儿52例作为实验研究对象。随机将其分成研究组和对照组，各26例，研究组患儿中男性和女性各13例，年龄2～27 d，平均年龄(14.5±1.3)d、体重2.8～3.6 kg，平均体重(3.2±0.55)kg；对照组患儿中男性14例，女性12例，该组患儿年龄4～27 d，平均年龄(15.5±1.5)d、体重2.65～3.5 kg，平均体重(3.6±0.65)kg，所有患儿家属同意本次研究。两组患儿性别、年龄等指标数据比较分析无统计学意义(P>0.05)，可以进行实验讨论。, 百拇医药(赵华 黄光菊)
关键词：新生儿窒息后心肌损伤；常规方案；磷酸肌酸钠
, http://www.100md.com
中图分类号：R722.12 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.01.052
文章编号：1006-1959(2018)01-0136-02
Effect of Sodium Phosphocreatine Injection in the Treatment of Myocardial Injury after Asphyxia Neonatorum
ZHAO Hua1，HUANG Guang-ju2
(Department of Pediatrics1，Department of surgery2，People's Hospital of Xingshan Province，Yichang 443700，Hubei，China)
, 百拇医药
Abstract：Objective To analyze the clinical effect of sodium creatine phosphate in neonatal asphyxia after myocardial injury.Methods In this study， 52 children with myocardial injury after asphyxia were randomly divided into study group and control group. Patients in study group were treated with sodium creatine phosphate injection and patients in control group were treated with conventional regimen. Results The clinical treatment of patients with total efficiency of 96.15% and left ventricular ejection fraction(0.65±0.08)%and left ventricular fractional shortening(0.49±0.06)%were significantly higher than the control group total effective rate 61.54% and left ventricular ejection fraction (0.30 ±0.01)%and left ventricular fractional shortening(0.16±0.05)%；At the same time， patients in the study group，creatine kinase MB(21.4±11.0)U/L and troponin I(0.03±0.01)ng/ml were significantly lower than the control group of patients with acid kinase isoenzyme(51.5±11.5)U/L and troponin I (0.12 ±0.03)ng/ml(P<0.05)，the group of children with better clinical effect.Conclusion The effect of creatine phosphate sodium is better in the treatment of myocardial injury after asphyxia.It can effectively improve the cardiac function，improve myocardial injury and promote the recovery of the body，and is of great significance in clinical application.
, 百拇医药
Key words：Myocardial injury after neonatal asphyxia；Routine regimen；Sodium phosphocreatine
根据临床实践发现[1]，新生儿在患病过程中容易出现窒息情况，患儿心肌缺血、供血异常，导致其肌酸激酶同工酶指标升高，诱发心肌损伤、威胁生命安全。窒息后心肌损伤最常见的表现有心律失常、心源性休克等[2]。本实验共选取2015年10月～2017年5月窒息后心肌损伤患儿52例，对其中26例患儿应用磷酸肌酸钠治疗，效果较好，现报道如下。
1 資料与方法
1.1 一般资料 将本院2015年10月～2017年5月收治的心肌损伤患儿52例作为实验研究对象。随机将其分成研究组和对照组，各26例，研究组患儿中男性和女性各13例，年龄2～27 d，平均年龄(14.5±1.3)d、体重2.8～3.6 kg，平均体重(3.2±0.55)kg；对照组患儿中男性14例，女性12例，该组患儿年龄4～27 d，平均年龄(15.5±1.5)d、体重2.65～3.5 kg，平均体重(3.6±0.65)kg，所有患儿家属同意本次研究。两组患儿性别、年龄等指标数据比较分析无统计学意义(P>0.05)，可以进行实验讨论。, 百拇医药(赵华 黄光菊)