呼吸兴奋剂尼可刹米+洛贝林联合纳洛酮与氟马西尼在重度安眠药物中毒抢救治疗中的效果观察(1)
摘 要：目的 研究并探讨呼吸兴奋剂(尼可刹米+洛贝林)联合纳洛酮与氟马西尼在重度安眠药物中毒抢救治疗中的临床疗效。方法 选取2014年1月～2017年8月我科收治的60例重度安眠藥物中毒患者，随机分为两组，各30例。对照组采用纳洛酮联合呼吸兴奋剂治疗，观察组采用氟马西尼联合呼吸兴奋剂治疗，两组在疗效、格拉斯哥昏迷指数、催醒时间、住院时间、不良反应等方面作比较。结果 观察组的总有效率(96.67%)明显高于对照组(80.00%)，差异具有统计学意义(P<0.05)；两组治疗后的GCS评分均显著增高，而治疗后观察组的GCS评分高于对照组，差异具有统计学意义(P<0.05)；观察组的催醒时间、住院时间均短于对照组，差异具有统计学意义(P<0.05)；两组不良反应相比差异无统计学意义(P>0.05)。结论 在重度安眠药物中毒患者急诊抢救治疗中，采用呼吸兴奋剂与氟马西尼联合治疗的催醒效果优于纳洛酮+呼吸兴奋剂，可作为重度安眠药物中毒的首选治疗方案。
关键词：安眠药物中毒；氟马西尼；纳洛酮；呼吸兴奋剂
, http://www.100md.com
中图分类号：R595.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.02.047
文章编号：1006-1959(2018)00-0128-03
Abstract：Objective To study and explore the clinical efficacy of respiratory stimulant(nikethamide+Lobeline)combined with naloxone and flumazenil in the treatment of severe hypnotic drug poisoning.Methods From January 2014 to August 2017，60 patients with severe hypnotic drug poisoning admitted to our department were randomly divided into two groups of 30 patients.The control group was treated with naloxone combined with respiratory stimulant.The observation group was treated with flumazenil combined with respiratory stimulant.The two groups were compared in efficacy， Glasgow coma index，wake time，length of hospital stay， and adverse reactions.Results The total effective rate(96.67%)in the observation group was significantly higher than that in the control group(80.00%)，the difference was statistically significant(P<0.05)；GCS scores of both groups were significantly increased after treatment，but after treatment，GCS score of the observation group was higher than that of the control group，the difference was statistically significant(P<0.05)；the awake time and hospitalization time of the observation group were shorter than the control group，the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion In the emergency rescue treatment of patients with severe hypnotic drug poisoning，the combination of respiratory stimulant and flumazenil is better than naloxone+respiratory stimulant，which can be used as the first choice of severe hypnotic drug poisoning treatment programs.
, 百拇医药
Key words：Sleeping pills poisoning；Flumacini；Naloxone；Respiratory stimulant
安眠药物多用于治疗失眠症患者，作为辅助睡眠药物，但由于安眠药物多为镇静药物，过量服用容易导致中毒，对患者的生命安全构成威胁[1]。重度安眠药物中毒后，患者多出现意识障碍，陷入昏迷状态，及时有效的抢救治疗是挽救患者生命的关键，其抢救以药物治疗为主，而采取何种药物治疗方案则尚未达成共识。故选取2014年1月～2017年8月我科收治的60例重度安眠药物中毒患者进行研究，以探讨呼吸兴奋剂联合纳洛酮与呼吸兴奋剂联合氟马西尼在重度安眠药物中毒抢救治疗中的临床疗效。
1资料与方法, http://www.100md.com(王大建)
关键词：安眠药物中毒；氟马西尼；纳洛酮；呼吸兴奋剂
, http://www.100md.com
中图分类号：R595.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.02.047
文章编号：1006-1959(2018)00-0128-03
Abstract：Objective To study and explore the clinical efficacy of respiratory stimulant(nikethamide+Lobeline)combined with naloxone and flumazenil in the treatment of severe hypnotic drug poisoning.Methods From January 2014 to August 2017，60 patients with severe hypnotic drug poisoning admitted to our department were randomly divided into two groups of 30 patients.The control group was treated with naloxone combined with respiratory stimulant.The observation group was treated with flumazenil combined with respiratory stimulant.The two groups were compared in efficacy， Glasgow coma index，wake time，length of hospital stay， and adverse reactions.Results The total effective rate(96.67%)in the observation group was significantly higher than that in the control group(80.00%)，the difference was statistically significant(P<0.05)；GCS scores of both groups were significantly increased after treatment，but after treatment，GCS score of the observation group was higher than that of the control group，the difference was statistically significant(P<0.05)；the awake time and hospitalization time of the observation group were shorter than the control group，the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion In the emergency rescue treatment of patients with severe hypnotic drug poisoning，the combination of respiratory stimulant and flumazenil is better than naloxone+respiratory stimulant，which can be used as the first choice of severe hypnotic drug poisoning treatment programs.
, 百拇医药
Key words：Sleeping pills poisoning；Flumacini；Naloxone；Respiratory stimulant
安眠药物多用于治疗失眠症患者，作为辅助睡眠药物，但由于安眠药物多为镇静药物，过量服用容易导致中毒，对患者的生命安全构成威胁[1]。重度安眠药物中毒后，患者多出现意识障碍，陷入昏迷状态，及时有效的抢救治疗是挽救患者生命的关键，其抢救以药物治疗为主，而采取何种药物治疗方案则尚未达成共识。故选取2014年1月～2017年8月我科收治的60例重度安眠药物中毒患者进行研究，以探讨呼吸兴奋剂联合纳洛酮与呼吸兴奋剂联合氟马西尼在重度安眠药物中毒抢救治疗中的临床疗效。
1资料与方法, http://www.100md.com(王大建)