阿奇霉素序贯疗法治疗小儿支原体肺炎的疗效观察(1)
摘 要：目的 观察并研究阿奇霉素序贯疗法治疗小儿支原体肺炎的临床疗效。方法 选择2015年3月～2017 年4月我院收治的84例小儿支原体肺炎患者作为研究对象，随机分为对照组40例和观察组44例。观察组采用阿奇霉素序贯疗法，对照组采用红霉素序贯疗法，观察两组患儿临床症状及体征改善情况，并比较两组临床疗效及不良反应情况。结果 观察组小儿支原体肺炎治疗总有效率(95.45%)高于对照组(82.50%)，差异有统计学意义(P<0.05)。观察组咳嗽气促症状改善(2.54±0.69)d、肺部啰音改善(3.14±0.97)d、发热消失时间(3.45±0.67)d和住院时间(7.24±1.38)d均低于对照组(3.79±1.04)d、(4.89±1.13)d、(4.73±0.89)d、(9.68±2.04)d，差异有统计学意义(P<0.05)。观察组不良反应发生率(11.36%)低于对照组(20.00%)， 差异有统计学意义(P<0.05)。结论 小儿支原体肺炎采用阿奇霉素序贯疗法治疗效果可靠，可快速改善患儿临床症状、体征，且毒副作用较小，有助于缩短患儿病程，提高疗效。
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关键词：阿奇霉素序贯疗法；小儿支原体肺炎；安全性
中图分类号：R725.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.003
文章编号：1006-1959(2018)04-0007-03
Abstract：Objective To observe and study the clinical efficacy of azithromycin sequential therapy in the treatment of mycoplasma pneumonia in children.Methods 84 cases of mycoplasma pneumonia in our hospital from March 2015 to April 2017 were selected as the subjects，and they were randomly divided into 40 cases in the control group and 44 in the observation group.The observation group was treated with azithromycin sequential therapy，while the control group was treated with erythromycin sequential therapy.The clinical symptoms and signs improvement of the two groups were observed，and the clinical efficacy and adverse reactions of the two groups were compared.Results The total effective rate of mycoplasma pneumonia in the observation group(95.45%)was higher than that of the control group(82.50%)，and the difference was statistically significant(P<0.05).In the observation group，the symptoms of cough and shortness of breath were improved(2.54±0.69)d，the lung rales were improved(3.14±0.97)d，the time of fever disappeared was(3.45±0.67)d，and the hospitalization time was(7.24±1.38)d，which was lower than that in the control group of(3.79±1.04)d，(4.89±1.13)d，(4.73±0.89)d，(9.68±2.04)d，the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group (11.36%)was lower than that in the control group(20.00%)，the difference was statistically significant(P<0.05).Conclusion Azithromycin sequential therapy for mycoplasma pneumonia in children is effective and can improve the clinical symptoms and signs of children with less side effects.It is helpful to shorten the course of disease and improve the curative effect of children with mycoplasma pneumoniae.
, http://www.100md.com
Key words：Azithromycin sequential therapy；Mycoplasma pneumonia in children；Safety
小兒支原体肺炎(mycoplasma pneumonia)是肺炎支原体感染引起的肺部急性炎症。儿童呼吸道发育尚不完善，小儿支原体肺炎发病率较高，且呈明显的季节性特征，秋冬季发病率呈明显上升趋势。小儿支原体肺炎病情进展较快，可迅速发展为严重肺部急性炎症病变，需尽快治疗。抗感染治疗是小儿支原体肺炎治疗的重点，而大环内脂类药物为首选抗生素，但是药物选择方面尚存在争议[1]。为此，本次研究选择2015年3月～2017 年4月我院收治的84例小儿支原体肺炎患者作为研究对象，对比分析了阿奇霉素序贯疗法的临床疗效，现报道如下。, http://www.100md.com(梁曼 赵俊芝)
, http://www.100md.com
关键词：阿奇霉素序贯疗法；小儿支原体肺炎；安全性
中图分类号：R725.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.003
文章编号：1006-1959(2018)04-0007-03
Abstract：Objective To observe and study the clinical efficacy of azithromycin sequential therapy in the treatment of mycoplasma pneumonia in children.Methods 84 cases of mycoplasma pneumonia in our hospital from March 2015 to April 2017 were selected as the subjects，and they were randomly divided into 40 cases in the control group and 44 in the observation group.The observation group was treated with azithromycin sequential therapy，while the control group was treated with erythromycin sequential therapy.The clinical symptoms and signs improvement of the two groups were observed，and the clinical efficacy and adverse reactions of the two groups were compared.Results The total effective rate of mycoplasma pneumonia in the observation group(95.45%)was higher than that of the control group(82.50%)，and the difference was statistically significant(P<0.05).In the observation group，the symptoms of cough and shortness of breath were improved(2.54±0.69)d，the lung rales were improved(3.14±0.97)d，the time of fever disappeared was(3.45±0.67)d，and the hospitalization time was(7.24±1.38)d，which was lower than that in the control group of(3.79±1.04)d，(4.89±1.13)d，(4.73±0.89)d，(9.68±2.04)d，the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group (11.36%)was lower than that in the control group(20.00%)，the difference was statistically significant(P<0.05).Conclusion Azithromycin sequential therapy for mycoplasma pneumonia in children is effective and can improve the clinical symptoms and signs of children with less side effects.It is helpful to shorten the course of disease and improve the curative effect of children with mycoplasma pneumoniae.
, http://www.100md.com
Key words：Azithromycin sequential therapy；Mycoplasma pneumonia in children；Safety
小兒支原体肺炎(mycoplasma pneumonia)是肺炎支原体感染引起的肺部急性炎症。儿童呼吸道发育尚不完善，小儿支原体肺炎发病率较高，且呈明显的季节性特征，秋冬季发病率呈明显上升趋势。小儿支原体肺炎病情进展较快，可迅速发展为严重肺部急性炎症病变，需尽快治疗。抗感染治疗是小儿支原体肺炎治疗的重点，而大环内脂类药物为首选抗生素，但是药物选择方面尚存在争议[1]。为此，本次研究选择2015年3月～2017 年4月我院收治的84例小儿支原体肺炎患者作为研究对象，对比分析了阿奇霉素序贯疗法的临床疗效，现报道如下。, http://www.100md.com(梁曼 赵俊芝)