妊娠期高血压疾病患者血浆ProBNP水平及其临床意义(1)
摘 要：目的 觀察妊娠期高血压疾病患者Pro BNP水平及临床意义。方法 选择在我院行剖宫产术的妊娠期高血压疾病患者89例为HDCP组，包括妊娠高血压24例，轻度子痫前期21例，重度子痫前期44例；同期在我院行剖宫产术的妊娠晚期健康妇女88例为对照组，采用电化学发光法检测各组Pro BNP并对比。结果 HDCP组Pro BNP为(844.02±788.74)pg/ml，显著高于对照组的(142.90±187.20)pg/ml，差异有统计学意义(P<0.05)。与对照组相比，轻度子痫前期组和重度子痫前期组Pro BNP均显著增高，差异有统计学意义(P<0.05)。与妊娠高血压组相比，轻度子痫前期组和重度子痫前期组Pro BNP显著增高，差异有统计学意义(P<0.05)。重度子痫前期组Pro BNP显著高于轻度子痫前期组，差异有统计学意义(P<0.05)。结论 妊娠期高血压疾病患者血浆Pro BNP水平高于妊娠晚期健康妇女，检测妊娠期高血压疾病患者血浆Pro BNP水平可及时了解早期心肌细胞损害及心脏功能情况，对了解病情、观察疗效和预后判断具有重要价值。
, 百拇医药
关键词：妊娠期高血压疾病；B型钠尿肽前体；剖宫产
中图分类号：R714.25 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.059
文章编号：1006-1959(2018)04-0158-02
Abstract：Objective To observe the level and clinical significance of Pro BNP in hypertensive disorder complicating pregnancy. Methods 89 patients with hypertensive disorder complicating pregnancy undergoing cesarean section in our hospital were selected as HDCP group including 24 cases of pregnancy-induced hypertension，21 cases of mild preeclampsia and 44 cases of severe preeclampsia.88 healthy women in the third trimester of pregnancy who underwent cesarean section in our hospital were used as normal control group.Electrochemiluminescence was used to detect Pro BNP in each group.Results The Pro BNP of HDCP group was (844.02±788.74)pg/ml，which was significantly higher than that of control group(142.90±187.20)pg/ml，the difference was statistically significant(P<0.05).Compared with the control group，the Pro BNP in the mild preeclampsia group and the severe preeclampsia group was significantly higher than that in the control group(P<0.05).There was no significant difference in Pro BNP in pregnancy hypertension group(P>0.05)Compared with pregnancy-induced hypertension group，ProBNP in mild preeclampsia group and severe preeclampsia group was significantly higher，the difference was statistically significant(P<0.05).ProBNP in severe preeclampsia group was significantly higher than that in mild preeclampsia group，the difference was statistically significant(P<0.05).Conclusion The level of plasma Pro BNP in hypertensive disorder complicating pregnancy is higher than that in healthy women in the third trimester of pregnancy.The detection of plasma Pro BNP level in patients with hypertensive disorder complicating pregnancy can timely understand the early myocardial cell damage and cardiac function，and it is of great value to understand the state of the disease， observe the curative effect and judge the prognosis.
Key words：Gestational hypertension disorder；Type B natriuretic peptide precursor；Cesarean section, 百拇医药(李欢 刘俊 夏军辉)
, 百拇医药
关键词：妊娠期高血压疾病；B型钠尿肽前体；剖宫产
中图分类号：R714.25 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.059
文章编号：1006-1959(2018)04-0158-02
Abstract：Objective To observe the level and clinical significance of Pro BNP in hypertensive disorder complicating pregnancy. Methods 89 patients with hypertensive disorder complicating pregnancy undergoing cesarean section in our hospital were selected as HDCP group including 24 cases of pregnancy-induced hypertension，21 cases of mild preeclampsia and 44 cases of severe preeclampsia.88 healthy women in the third trimester of pregnancy who underwent cesarean section in our hospital were used as normal control group.Electrochemiluminescence was used to detect Pro BNP in each group.Results The Pro BNP of HDCP group was (844.02±788.74)pg/ml，which was significantly higher than that of control group(142.90±187.20)pg/ml，the difference was statistically significant(P<0.05).Compared with the control group，the Pro BNP in the mild preeclampsia group and the severe preeclampsia group was significantly higher than that in the control group(P<0.05).There was no significant difference in Pro BNP in pregnancy hypertension group(P>0.05)Compared with pregnancy-induced hypertension group，ProBNP in mild preeclampsia group and severe preeclampsia group was significantly higher，the difference was statistically significant(P<0.05).ProBNP in severe preeclampsia group was significantly higher than that in mild preeclampsia group，the difference was statistically significant(P<0.05).Conclusion The level of plasma Pro BNP in hypertensive disorder complicating pregnancy is higher than that in healthy women in the third trimester of pregnancy.The detection of plasma Pro BNP level in patients with hypertensive disorder complicating pregnancy can timely understand the early myocardial cell damage and cardiac function，and it is of great value to understand the state of the disease， observe the curative effect and judge the prognosis.
Key words：Gestational hypertension disorder；Type B natriuretic peptide precursor；Cesarean section, 百拇医药(李欢 刘俊 夏军辉)