Lp-PLA2血小板相关因子与2型糖尿病合并高血压病的相关性研究(1)
摘 要：目的 探討脂蛋白相关性磷脂酶A2(Lp-PLA2)、血小板相关因子与2型糖尿病合并高血压病患者的相关性。方法 连续入选我院2型糖尿病患者共102例，分为2型糖尿病合并高血压病组(n=50)、单纯2型糖尿病组(n=52)，以及同期住院的单纯高血压病组(n=30)、体检健康对照组(n=30)。记录四组患者一般资料、生化指标及血小板相关因子--血小板计数(PLT)、血小板分布宽度(PDW)、平均血小板容积(MPV)及大血小板比率(P-LCR)水平，并测定Lp-PLA2水平。结果 四组间性别、年龄、ALT、AST、Scr、BUN、TCH比较，差异无统计学意义(P>0.05)。2型糖尿病合并高血压病患者的Lp-PLA2及PDW、MPV、P-LCR水平较单纯2型糖尿病患者、单纯高血压病组及健康对照组升高，差异有统计学意义(P<0.05);PLT较单纯2型糖尿病组、单纯高血压病组及健康对照组降低，差异有统计学意义(P<0.05)。Lp-PLA2、PDW与收缩压(SBP)成正相关(P<0.05)，Lp-PLA2、PDW、MPW、P-LCT与糖化血红蛋白(HbA1c)成正相关(P<0.05)。结论 Lp-PLA2、血小板相关因子可评估2型糖尿病患者血管内皮功能状态，合并高血压病的2型糖尿病患者血管内皮功能障碍更加严重，且该严重程度与血压、血糖控制不佳的程度有关。
, http://www.100md.com
关键词：2型糖尿病;高血压病;Lp-PLA2;血小板相关因子
中图分类号：R587.1;R544.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.05.002
文章编号：1006-1959(2018)05-0003-05
Study on the Correlation between Lp-PLA2 Platelet-associated Factors and Type 2 Diabetes Mellitus Complicated with Hypertension
CAO Lan1，HOU Rui-tian2，WANG Fu-hui1，GE Xiao-chun2，HE Jian-qiu2，ZHEN Jiang-wei1，JIN Feng-biao2
, http://www.100md.com
(1.Chengde Medical College，Chengde 067000，Hebei，China;
2.Department of Endocrinology，Affiliated Hospital of Chengde Medical College，Chengde 067000，Hebei，China)
Abstract：Objective To investigate the relationship between lipoprotein associated phospholipase A2(Lp-PLA2)，platelet related factors and type 2 diabetes mellitus complicated with hypertension.Methods 102 patients with type 2 diabetes mellitus were enrolled in our hospital.The patients were divided into two groups：type 2 diabetes mellitus complicated with hypertension group(n=50)，type 2 diabetes group(n=52)，hypertension group(n=30)and healthy control group(n=30).The general data， biochemical parameters and platelet related factor-platelet count(PLT)，platelet distribution width(PDW)，mean platelet volume(MPV)and large platelet ratio(P-LCR)were recorded in the four groups，and the level of Lp-PLA2 was measured.Results There was no significant difference in the age，sex，ALT，AST，Scr，BUN，TCH among the four groups(P>0.05).Type 2 diabetes mellitus and hypertension in patients with Lp-PLA2 and PDW， MPV and P-LCR levels higher than patients with type 2 diabetes mellitus，hypertension group and healthy control group increased，the difference was statistically significant(P<0.05);PLT compared with type 2 diabetes group and simple hypertension group and healthy control group decreased，with statistical significance the difference(P<0.05).Lp-PLA2 and PDW were positively correlated with systolic blood pressure(SBP)(P<0.05)，and Lp-PLA2，PDW，MPW and P-LCT were positively correlated with glycosylated hemoglobin(HbA1c) (P<0.05).Conclusion Lp-PLA2 and platelet related factors can evaluate endothelial function in patients with type 2 diabetes mellitus， and endothelial dysfunction is more severe in type 2 diabetic patients with hypertension，and the severity is related to the degree of blood pressure and blood sugar control., http://www.100md.com(曹岚 侯瑞田 王福慧 葛晓春 何建秋 甄江伟 金凤表)
, http://www.100md.com
关键词：2型糖尿病;高血压病;Lp-PLA2;血小板相关因子
中图分类号：R587.1;R544.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.05.002
文章编号：1006-1959(2018)05-0003-05
Study on the Correlation between Lp-PLA2 Platelet-associated Factors and Type 2 Diabetes Mellitus Complicated with Hypertension
CAO Lan1，HOU Rui-tian2，WANG Fu-hui1，GE Xiao-chun2，HE Jian-qiu2，ZHEN Jiang-wei1，JIN Feng-biao2
, http://www.100md.com
(1.Chengde Medical College，Chengde 067000，Hebei，China;
2.Department of Endocrinology，Affiliated Hospital of Chengde Medical College，Chengde 067000，Hebei，China)
Abstract：Objective To investigate the relationship between lipoprotein associated phospholipase A2(Lp-PLA2)，platelet related factors and type 2 diabetes mellitus complicated with hypertension.Methods 102 patients with type 2 diabetes mellitus were enrolled in our hospital.The patients were divided into two groups：type 2 diabetes mellitus complicated with hypertension group(n=50)，type 2 diabetes group(n=52)，hypertension group(n=30)and healthy control group(n=30).The general data， biochemical parameters and platelet related factor-platelet count(PLT)，platelet distribution width(PDW)，mean platelet volume(MPV)and large platelet ratio(P-LCR)were recorded in the four groups，and the level of Lp-PLA2 was measured.Results There was no significant difference in the age，sex，ALT，AST，Scr，BUN，TCH among the four groups(P>0.05).Type 2 diabetes mellitus and hypertension in patients with Lp-PLA2 and PDW， MPV and P-LCR levels higher than patients with type 2 diabetes mellitus，hypertension group and healthy control group increased，the difference was statistically significant(P<0.05);PLT compared with type 2 diabetes group and simple hypertension group and healthy control group decreased，with statistical significance the difference(P<0.05).Lp-PLA2 and PDW were positively correlated with systolic blood pressure(SBP)(P<0.05)，and Lp-PLA2，PDW，MPW and P-LCT were positively correlated with glycosylated hemoglobin(HbA1c) (P<0.05).Conclusion Lp-PLA2 and platelet related factors can evaluate endothelial function in patients with type 2 diabetes mellitus， and endothelial dysfunction is more severe in type 2 diabetic patients with hypertension，and the severity is related to the degree of blood pressure and blood sugar control., http://www.100md.com(曹岚 侯瑞田 王福慧 葛晓春 何建秋 甄江伟 金凤表)