辅助生殖技术中卵巢过度刺激综合征发生发展预测指标的研究(1)
摘 要：目的 研究辅助生殖技术中卵巢过度刺激综合征发生发展预测指标。方法 回顾分析2016年8月～2017年8月在我院接受辅助生殖技术(ART)治疗的52例卵巢过度刺激综合征(OHSS)(分为早发组25例和晚发组27例)和40例非OHSS患者，比较两组患者妊娠结局等指标，筛查OHSS发生发展预测指标。结果 OHSS组患者妊娠率、不良妊娠率、多胎妊娠率高于非OHSS组，差异有统计学意义(P<0.05)；早发组年龄、促性腺激素(Gn)用量、HCG注射日中小卵泡评分与晚发组对比差异有统计学意义(P<0.05)，妊娠率、不良妊娠率组间对比，差异无统计学意义(P>0.05)；中小卵泡评分变量与OHSS发生时间相关，OHSS持续时间与是否妊娠或多胎妊娠相关。结论 早发的OHSS与卵巢对外源性HCG过度反应相关，HCG注射日中小卵泡评分可预测OHSS的发生。晚发的OHSS与胚胎中内源性HCG相关，OHSS持续时间可以预测判断妊娠情况。
关键词：辅助生殖技术；卵巢过度刺激综合征；预测指标
, 百拇医药
中图分类号：R711.75 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.07.032
文章编号：1006-1959(2018)07-0101-03
Research on Predictive Indexes of Occurrence and Development of Ovarian Hyperstimulation Syndrome in Assisted Reproductive Technology
JIANG Yu-ying
(Department of Obstetrics and Gynecology，Tianjin Harmony Hospital，Tianjin 300221，China)
, 百拇医药
Abstract：Objective To study the prediction of the development of ovarian hyperstimulation syndrome in assisted reproductive technology.Methods Retrospective analysis of August 2016～August 2017 in our hospital undergoing assisted reproductive technology (ART)treatment of 52 cases of ovarian hyperstimulation syndrome(OHSS)(divided into early-onset group 25 cases and 27 cases of late onset group)and 40 cases of non OHSS patients，compared two groups of patients with pregnancy outcomes，predictors of the occurrence and development of screening OHSS.Results The pregnancy rate and pregnancy rate of OHSS in patients with adverse pregnancy rate and multiple pregnancy higher than non OHSS group，the difference was statistically significant(P<0.05)；There was significant difference in age，gonadotropin(Gn)dosage，and small and medium-sized follicle score between HCG injection and late-onset group in the early-onset group(P<0.05).There was no statistically significant difference in pregnancy rate and adverse pregnancy rate between groups(P>0.05)；the small and medium-sized follicle scoring variables are related to the time of OHSS occurrence，and the duration of OHSS is related to whether it is a pregnancy or a multiple pregnancy.Conclusion The early-onset OHSS is related to the ovarian hyper-responsiveness to exogenous HCG，and the small and medium-sized follicle score of HCG injection can predict the occurrence of OHSS.Late-onset OHSS is associated with endogenous HCG in embryos，and the duration of OHSS can predict pregnancy outcomes.
, http://www.100md.com
Key words：Assisted reproductive technology；Ovarian hyperstimulation syndrome；Predictive indicators
卵巢過度刺激综合症(ovarian hyperstimulation syndrome，OHSS)是指采用辅助生殖技术治疗不孕症患者过程中，人体对促排卵性药物的刺激产生过度的反应，是临床常见的并发症[1]。临床通常会引起卵巢增大、胸腹水，严重时会出现电解质紊乱、凝血功能障碍等，甚至会危及患者的生命安全[2]。所以，临床分析OHSS的特点、相关因素、妊娠结局，建立有效的预测指标，为临床提供有效的指导，进一步有效预防OHSS的发生。本文作者结合2016年8月～2017年8月在我院接受辅助生殖技术(ART)治疗的患者临床资料，进行进一步的探究，现报告如下。, http://www.100md.com(姜玉滢)
关键词：辅助生殖技术；卵巢过度刺激综合征；预测指标
, 百拇医药
中图分类号：R711.75 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.07.032
文章编号：1006-1959(2018)07-0101-03
Research on Predictive Indexes of Occurrence and Development of Ovarian Hyperstimulation Syndrome in Assisted Reproductive Technology
JIANG Yu-ying
(Department of Obstetrics and Gynecology，Tianjin Harmony Hospital，Tianjin 300221，China)
, 百拇医药
Abstract：Objective To study the prediction of the development of ovarian hyperstimulation syndrome in assisted reproductive technology.Methods Retrospective analysis of August 2016～August 2017 in our hospital undergoing assisted reproductive technology (ART)treatment of 52 cases of ovarian hyperstimulation syndrome(OHSS)(divided into early-onset group 25 cases and 27 cases of late onset group)and 40 cases of non OHSS patients，compared two groups of patients with pregnancy outcomes，predictors of the occurrence and development of screening OHSS.Results The pregnancy rate and pregnancy rate of OHSS in patients with adverse pregnancy rate and multiple pregnancy higher than non OHSS group，the difference was statistically significant(P<0.05)；There was significant difference in age，gonadotropin(Gn)dosage，and small and medium-sized follicle score between HCG injection and late-onset group in the early-onset group(P<0.05).There was no statistically significant difference in pregnancy rate and adverse pregnancy rate between groups(P>0.05)；the small and medium-sized follicle scoring variables are related to the time of OHSS occurrence，and the duration of OHSS is related to whether it is a pregnancy or a multiple pregnancy.Conclusion The early-onset OHSS is related to the ovarian hyper-responsiveness to exogenous HCG，and the small and medium-sized follicle score of HCG injection can predict the occurrence of OHSS.Late-onset OHSS is associated with endogenous HCG in embryos，and the duration of OHSS can predict pregnancy outcomes.
, http://www.100md.com
Key words：Assisted reproductive technology；Ovarian hyperstimulation syndrome；Predictive indicators
卵巢過度刺激综合症(ovarian hyperstimulation syndrome，OHSS)是指采用辅助生殖技术治疗不孕症患者过程中，人体对促排卵性药物的刺激产生过度的反应，是临床常见的并发症[1]。临床通常会引起卵巢增大、胸腹水，严重时会出现电解质紊乱、凝血功能障碍等，甚至会危及患者的生命安全[2]。所以，临床分析OHSS的特点、相关因素、妊娠结局，建立有效的预测指标，为临床提供有效的指导，进一步有效预防OHSS的发生。本文作者结合2016年8月～2017年8月在我院接受辅助生殖技术(ART)治疗的患者临床资料，进行进一步的探究，现报告如下。, http://www.100md.com(姜玉滢)