PI3K/Akt信号通路及其抑制剂的研究进展(4)
[10]Gao Y，Ishiyama H，Sun M，et al.The alkylphospholipid，perifosine，radiosensitizes prostate cancer cells both in vitro and in vivo[J].Radiat Oncol，2011，6：39.
[11]Heavey S，O'Byrne KJ，Gately K.Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC[J].Cancer Treat Rev，2014，40(4)：445-456.
[12]Kharas MG，Janes MR，Scarfone VM，et al.Ablation of PI3K blocks BCR-ABL leukemogenesis in mice，and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells[J].J Clin Invest，2008，118(9)：3038-3050.
[13]Maira SM，Stauffer F，Brueggen J，et al.Identification and characterization of NVP-BEZ235，a new orally available dual phosphatidylinositol 3-kinase mammalian target of rapamycin inhibitor with potent in vivo antitumor activity[J].Mol Cancer Ther，2008，7(7)：1851-1863.
[14]Hong SW，Shin JS，Moon JH，et al.NVP-BEZ235，a dual PI3K/mTOR inhibitor，induces cell death through alternate routes in prostate cancer cells depending on the PTEN genotype[J].Apoptosis，2014，19(5)：895-904.
[15]Zhu W，Fu W，Hu L.NVP-BEZ235，dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor，prominently enhances radiosensitivity of prostate cancer cell line PC-3[J].Cancer Biother Radiopharm，2013，28(9)：665-673.
收稿日期：2018-3-7；修回日期：2018-3-26
編辑/王朵梅, http://www.100md.com(王梦华 卢均坤)
[11]Heavey S，O'Byrne KJ，Gately K.Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC[J].Cancer Treat Rev，2014，40(4)：445-456.
[12]Kharas MG，Janes MR，Scarfone VM，et al.Ablation of PI3K blocks BCR-ABL leukemogenesis in mice，and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells[J].J Clin Invest，2008，118(9)：3038-3050.
[13]Maira SM，Stauffer F，Brueggen J，et al.Identification and characterization of NVP-BEZ235，a new orally available dual phosphatidylinositol 3-kinase mammalian target of rapamycin inhibitor with potent in vivo antitumor activity[J].Mol Cancer Ther，2008，7(7)：1851-1863.
[14]Hong SW，Shin JS，Moon JH，et al.NVP-BEZ235，a dual PI3K/mTOR inhibitor，induces cell death through alternate routes in prostate cancer cells depending on the PTEN genotype[J].Apoptosis，2014，19(5)：895-904.
[15]Zhu W，Fu W，Hu L.NVP-BEZ235，dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor，prominently enhances radiosensitivity of prostate cancer cell line PC-3[J].Cancer Biother Radiopharm，2013，28(9)：665-673.
收稿日期：2018-3-7；修回日期：2018-3-26
編辑/王朵梅, http://www.100md.com(王梦华 卢均坤)