公安民警皮肤软纤维瘤与代谢综合征危险因素相关性研究(1)
摘 要：目的 比較公安民警皮肤软纤维瘤患者和正常对照组代谢综合征的基础危险因素指标，探讨皮肤软纤维瘤与代谢综合征危险因素相关性。研究皮肤软纤维瘤患者皮损IGF-1受体的表达，探讨皮肤软纤维瘤发病机制。方法 选取2016年5月～2017年11月来我院皮肤科就诊的公安民警软纤维瘤患者100例作为观察组，选取一般资料与观察组匹配的正常人100例作为对照组。比较两组空腹血糖、空腹胰岛素、动脉血压、血清甘油三酯(TG)、低密度脂蛋白(LDL-C)、身高、体重等指标。计算和比较两组体质指数(BMI)和胰岛素抵抗指数(HOMA-IR)。采用免疫组化Elivision法，比较两组胰岛素样生长因子受体表达的差异，半定量分析。结果 观察组患者空腹血糖、空腹胰岛素、动脉血压、TG、LDL-C、基础危险因素指标均高于对照组，差异具有统计学意义(P<0.05)。观察组患者的BMI和HOMA-IR高于对照组，差异具有统计学意义(P<0.05)。皮肤软纤维瘤皮损IGF-1R的表达阳性率为59.00%，高于正常皮肤的31.00%，差异有统计学意义(P<0.05)。结论 皮肤软纤维瘤与代谢综合征可能存在相关性，皮肤软纤维瘤的发病机制可能与胰岛素抵抗有关。
关键词：软纤维瘤；代谢综合征；胰岛素抵抗；IGF-1R
中图分类号：R739.5；R589 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.021
文章编号：1006-1959(2018)10-0069-04
Correlative Study on Skin Soft Fibroma and Risk Factors of Metabolic Syndrome in Public Security Police
LV Ning1，XU Xin2，HUANG Yong1，XU Lin3，SUN Nan1
(Department of Dermatology1，Department of Traditional Chinese Medicine2，Department of Pathology3，Tianjin Public Security Hospital， Tianjin 300042，China)
Abstract：Objective To compare the basic risk factors of metabolic syndrome in the patients with soft skin fibroma of the public security police and the normal control group，and to investigate the correlation between soft skin fibroids and risk factors of metabolic syndrome.To investigate the expression of IGF-1 receptor in skin lesions of soft skin fibroids and to explore the pathogenesis of soft skin fibroids.Methods From May 2016 to November 2017，100 cases of soft fibroma of public security police in Department of Dermatology in our hospital were taken as observation group，and 100 normal persons，which were matched with the observation group， were selected as the control group.Fasting blood glucose，fasting insulin，arterial blood pressure，serum triglyceride(TG)，low density lipoprotein(LDL-C)，height and weight were compared between the two groups.Two groups of body mass index(BMI)and insulin resistance index(HOMA-IR)were calculated and compared.The expression of insulin-like growth factor receptor(IGF)was compared between the two groups by immunohistochemical Elivision method.Results The indexes of fasting blood glucose， fasting insulin， arterial blood pressure，TG，LDL-C and basic risk factors in the observation group were all higher than those in the control group，and the difference was statistically significant(P<0.05).The BMI and HOMA-IR of the observation group were significantly higher than those of the control group，and the difference was statistically significant(P<0.05).The positive rate of IGF-1R expression in skin soft fibroma lesions was 59.00%，which was higher than 31.00% of normal skin，and the difference was statistically significant(P<0.05). Conclusion Cutaneous fibromatosis may be associated with metabolic syndrome.The pathogenesis of cutaneous fibromatosis may be related to insulin resistance.(吕宁 徐昕 黄永)