核黄素磷酸钠联合干扰素治疗小儿疱疹性咽峡炎的疗效观察(1)
摘 要：目的 观察核黄素磷酸钠联合干扰素治疗小儿疱疹性咽峡炎的临床疗效。方法 选取2016年5月～2017年10月在我院治疗的72例小儿疱疹性咽峡炎患儿临床资料为研究对象，将其随机分为对照组和观察组，每组36例。对照组采用干扰素治疗，观察组在对照组基础上联合应用核黄素磷酸钠治疗，对比两组患者治疗总有效率、体征平均消退时间、住院时间和不良反应情况。结果 观察组治疗有效率为91.67%，高于对照组的77.78%，差异具有统计学意义(P<0.05)；观察组患儿体征平均消退时间为(2.88±1.20)d，住院时间为(5.87±1.66)d，分别短于对照组的(3.14±1.11)d，(7.53±0.95)d，差异有统计学意义(P<0.05)；观察组不良反应发生率为8.33%，低于对照组的22.22%，差异有统计学意义(P<0.05)。结论 核黄素磷酸钠联合干扰素治疗小儿疱疹性咽峡炎可快速改善患儿临床症状，且临床不良反应少，具有临床应用和推广的重要价值。
关键词：核黄素磷酸钠；干扰素；疱疹性咽峡炎
, 百拇医药
中图分类号：R766.12 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.046
文章编号：1006-1959(2018)10-0138-03
Therapeutic Effect of Riboflavin Sodium Phosphate Combined with Interferon on Pediatric Herpangina
YIN Jing-hua
(Department of Pediatrics，Fengdu Traditional Chinese Medicine Hospital，Chongqing 408200，China)
Abstract：Objective To observe the clinical efficacy of riboflavin sodium phosphate combined with interferon in the treatment of pediatric herpangina.Methods The clinical data of 72 children with herpes isthmus treated in our hospital from May 2016 to October 2017 were randomly divided into control group(n=36)and observation group(n=36).The control group was treated with interferon，the observation group was treated with riboflavin sodium phosphate on the basis of the control group，and the total effective rate，mean regression time of signs，hospitalization time and adverse reactions were compared between the two groups.Results The effective rate was 91.67% in the observation group，which was 77.78% higher than that in the control group，the difference was statistically significant(P<0.05).The mean extinction time of the observation group was (2.88±1.20)d，and the length of hospital stay was(5.87±1.66) d，which was shorter than that of the control group (3.14±1.11)d，(7.53±0.95)d，the difference was statistically significant(P<0.05)；the incidence of adverse reactions in the observation group was 8.33%，which was lower than the 22.22% of the control group，and the difference was statistically significant(P<0.05).Conclusion The combination of riboflavin sodium phosphate and interferon in the treatment of pediatric herpangina can rapidly improve the clinical symptoms of children，and there are few clinical adverse reactions.It has important clinical application and promotion value.
, 百拇医药
Key words：Riboflavin sodium phosphate；Interferon；Herpetic angina
小兒疱疹性咽峡炎(pediatric herpangina)是临床常见的一种急性传染病，主要由柯萨奇病毒感染造成，临床有咽部充血，软腭、鄂咽弓的黏膜上可见数个疱疹，且伴有高热、咽痛、头痛等症状[1]。临床严重者可造成重要脏器功能损伤，严重影响患儿的健康生长。目前临床治疗小儿疱疹性咽峡炎主要采用抗病毒、抗生素等对症治疗，但是并发症发生率较高。干扰素是广谱抗病毒药物，具有良好的抗病毒作用，且临床不良反应少，在临床中应用广泛[2]。本次研究结合2016年5月～2017年10月在我院治疗的72例小儿疱疹性咽峡炎患儿临床资料，分析核黄素磷酸钠联合干扰素治疗小儿疱疹性咽峡炎的临床疗效，现报告如下。, http://www.100md.com(尹静华)
关键词：核黄素磷酸钠；干扰素；疱疹性咽峡炎
, 百拇医药
中图分类号：R766.12 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.046
文章编号：1006-1959(2018)10-0138-03
Therapeutic Effect of Riboflavin Sodium Phosphate Combined with Interferon on Pediatric Herpangina
YIN Jing-hua
(Department of Pediatrics，Fengdu Traditional Chinese Medicine Hospital，Chongqing 408200，China)
Abstract：Objective To observe the clinical efficacy of riboflavin sodium phosphate combined with interferon in the treatment of pediatric herpangina.Methods The clinical data of 72 children with herpes isthmus treated in our hospital from May 2016 to October 2017 were randomly divided into control group(n=36)and observation group(n=36).The control group was treated with interferon，the observation group was treated with riboflavin sodium phosphate on the basis of the control group，and the total effective rate，mean regression time of signs，hospitalization time and adverse reactions were compared between the two groups.Results The effective rate was 91.67% in the observation group，which was 77.78% higher than that in the control group，the difference was statistically significant(P<0.05).The mean extinction time of the observation group was (2.88±1.20)d，and the length of hospital stay was(5.87±1.66) d，which was shorter than that of the control group (3.14±1.11)d，(7.53±0.95)d，the difference was statistically significant(P<0.05)；the incidence of adverse reactions in the observation group was 8.33%，which was lower than the 22.22% of the control group，and the difference was statistically significant(P<0.05).Conclusion The combination of riboflavin sodium phosphate and interferon in the treatment of pediatric herpangina can rapidly improve the clinical symptoms of children，and there are few clinical adverse reactions.It has important clinical application and promotion value.
, 百拇医药
Key words：Riboflavin sodium phosphate；Interferon；Herpetic angina
小兒疱疹性咽峡炎(pediatric herpangina)是临床常见的一种急性传染病，主要由柯萨奇病毒感染造成，临床有咽部充血，软腭、鄂咽弓的黏膜上可见数个疱疹，且伴有高热、咽痛、头痛等症状[1]。临床严重者可造成重要脏器功能损伤，严重影响患儿的健康生长。目前临床治疗小儿疱疹性咽峡炎主要采用抗病毒、抗生素等对症治疗，但是并发症发生率较高。干扰素是广谱抗病毒药物，具有良好的抗病毒作用，且临床不良反应少，在临床中应用广泛[2]。本次研究结合2016年5月～2017年10月在我院治疗的72例小儿疱疹性咽峡炎患儿临床资料，分析核黄素磷酸钠联合干扰素治疗小儿疱疹性咽峡炎的临床疗效，现报告如下。, http://www.100md.com(尹静华)