红细胞分布宽度联合D—二聚体含量预测急性胰腺炎严重程度的价值(1)
摘 要：目的 探讨红细胞分布宽度联合D-二聚体含量预测急性胰腺炎严重程度的价值。方法 選取2016年1月～2017年11月在宁夏医科大学总医院的199例诊断急性胰腺炎患者作为研究对象，按照病情严重程度分为重症急性胰腺炎(SAP)组(n=91)与非重症急性胰腺炎(非SAP)组(n=108)，收集所有患者入院后12 h内且未经治疗的外周血检测SD与纤溶系统D-D，采用ROC曲线分析SD、D-D及两指标联合对AP病情严重程度价值。结果 SAP组患者SD值和D-D值均比非SAP组高，组间比较差异有统计学意义(P<0.05)，外周血SD和血浆D-D与AP病情严重程度均呈正相关(r分别为0.423、0.664，P分别为0.001，0.005)。SD、D-D及两指标联合的受试者工作特征曲线面积(AUC)分别为0.745、0.876、0.896，其特异度分别为0.648、0.725、0.780，SD联合D-D检测后可增加ROC曲线下面积和诊断特异度。SD和D-D值与SAP密切相关，其值越高，发生SAP可能性越大。结论 SD联合D-D检测在预测AP严重程度上具有一定的临床意义。
, 百拇医药
关键词：重症急性胰腺炎；红细胞分布宽度；D-二聚体含量
中图分类号：R576 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.022
文章编号：1006-1959(2018)12-0073-03
Abstract：Objective To investigate the value of red blood cell distribution width combined with D-dimer content in predicting the severity of acute pancreatitis.Methods From January 2016 to November 2017，199 patients with acute pancreatitis diagnosed in the General Hospital of Ningxia Medical University were selected as subjects.According to the severity of the disease，the patients were divided into severe acute pancreatitis(SAP)group(n=91)and non-severe acute pancreatitis(non-SAP)group(n=108).All patients were collected for 12 h after admission and untreated peripherals.Blood test SD and fibrinolytic system D-D，using ROC curve analysis of SD，D-D and the combination of the two indicators of the AP disease severity value.Results The SD and DD values of the SAP group were higher than those of the non-SAP group，the difference between the two groups was statistically significant(P<0.05).Peripheral blood SD and plasma D-D were positively correlated with the severity of AP(r respectively 0.423，0.664，P respectively，0.001，0.005). The receiver operating characteristic curve area(AUC)of SD，D-D and two indicators was 0.745，0.876，and 0.896，respectively，and their specificities were 0.648，0.725，and 0.780，respectively.SD combined with DD could increase the area under the ROC curve and diagnose specificity.SD and D-D values are closely related to SAP，and the higher the value，the greater the likelihood of SAP occurring.Conclusion SD combined with D-D detection has certain clinical significance in predicting the severity of AP.
, 百拇医药
Key words：Severe acute pancreatitis；Red blood cell distribution width；D-dimer content
急性胰腺炎(acute pancreatitis，AP)是临床急腹症常见的一种，起病急，病情发展迅速，并发症多，死亡率高的特点。其中SAP病情重而凶险，预后差，死亡率在40%[1]以上，并逐年有上升趋势，早期评估AP严重程度对改善病情预后具有重要意义。目前临床常用血淀粉酶、脂肪酶、尿淀粉酶、血钙、血糖及腹部增强CT、腹部B超对诊断AP具有重要价值，其中腹部增强CT可评估AP病情严重程度，但所需时间长，价格高，放射风险及有局限性等，不利于早期诊断。故目前需要方便、经济的方式评估AP的病情严重程度。有关研究[2]D-二聚体含量有助于判断AP患者病情严重程度。红细胞分布宽度可以预测危重患者疾病预后[3]，但目前很少有两指标联合检测对AP诊断及病情预测的相关报道。本研究旨在探讨红细胞分布宽度(SD)联合血浆D-二聚体含量(D-D)检测对AP患者病情严重程度的临床价值。, http://www.100md.com(车鹏博 阮继刚 郭丹)
, 百拇医药
关键词：重症急性胰腺炎；红细胞分布宽度；D-二聚体含量
中图分类号：R576 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.022
文章编号：1006-1959(2018)12-0073-03
Abstract：Objective To investigate the value of red blood cell distribution width combined with D-dimer content in predicting the severity of acute pancreatitis.Methods From January 2016 to November 2017，199 patients with acute pancreatitis diagnosed in the General Hospital of Ningxia Medical University were selected as subjects.According to the severity of the disease，the patients were divided into severe acute pancreatitis(SAP)group(n=91)and non-severe acute pancreatitis(non-SAP)group(n=108).All patients were collected for 12 h after admission and untreated peripherals.Blood test SD and fibrinolytic system D-D，using ROC curve analysis of SD，D-D and the combination of the two indicators of the AP disease severity value.Results The SD and DD values of the SAP group were higher than those of the non-SAP group，the difference between the two groups was statistically significant(P<0.05).Peripheral blood SD and plasma D-D were positively correlated with the severity of AP(r respectively 0.423，0.664，P respectively，0.001，0.005). The receiver operating characteristic curve area(AUC)of SD，D-D and two indicators was 0.745，0.876，and 0.896，respectively，and their specificities were 0.648，0.725，and 0.780，respectively.SD combined with DD could increase the area under the ROC curve and diagnose specificity.SD and D-D values are closely related to SAP，and the higher the value，the greater the likelihood of SAP occurring.Conclusion SD combined with D-D detection has certain clinical significance in predicting the severity of AP.
, 百拇医药
Key words：Severe acute pancreatitis；Red blood cell distribution width；D-dimer content
急性胰腺炎(acute pancreatitis，AP)是临床急腹症常见的一种，起病急，病情发展迅速，并发症多，死亡率高的特点。其中SAP病情重而凶险，预后差，死亡率在40%[1]以上，并逐年有上升趋势，早期评估AP严重程度对改善病情预后具有重要意义。目前临床常用血淀粉酶、脂肪酶、尿淀粉酶、血钙、血糖及腹部增强CT、腹部B超对诊断AP具有重要价值，其中腹部增强CT可评估AP病情严重程度，但所需时间长，价格高，放射风险及有局限性等，不利于早期诊断。故目前需要方便、经济的方式评估AP的病情严重程度。有关研究[2]D-二聚体含量有助于判断AP患者病情严重程度。红细胞分布宽度可以预测危重患者疾病预后[3]，但目前很少有两指标联合检测对AP诊断及病情预测的相关报道。本研究旨在探讨红细胞分布宽度(SD)联合血浆D-二聚体含量(D-D)检测对AP患者病情严重程度的临床价值。, http://www.100md.com(车鹏博 阮继刚 郭丹)