喜炎平注射液治疗社区获得性肺炎临床疗效的Meta分析(1)
摘 要：目的 評价喜炎平注射液治疗****获得性肺炎的临床疗效。方法 检索国内外公开发表的有关喜炎平注射液治疗社区获得性肺炎的随机对照试验研究，观察指标包括临床总有效率、咳嗽消失时间、啰音消失时间、退热时间、白细胞计数、降钙素原)、C-反应蛋白。结果 最终纳入13篇文献，Meta分析结果显示：喜炎平注射液组与对照组相比，临床总有效率提高：比值比为4.24，95%置信区间2.93～6.14，P<0.00001；咳嗽消失时间缩短：加权均数差为-2.67，95CI：-3.91～-1.44，P<0.0001；啰音消失时间缩短：标准化均数差为-0.91，95%CI：-1.16～-0.66，P<0.0001；退热时间缩短：WMD为-1.83，95%CI：-2.92～-0.74，P=0.001；WBC水平无明显变化： WMD为-1.14，95%CI：-2.77～0.48，P=0.17；PCT水平降低：SMD为-1.86，95%CI：-3.02～-0.70，P=0.002；CRP水平降低： SMD为-1.86，95%CI：-2.82～-0.89，P=0.0002。结论 在常规西医治疗基础上加用喜炎平注射液治疗CAP可以明显提高患者临床总有效率，缩短咳嗽、啰音、发热持续时间，降低患者体内PCT、CRP水平，但对降低患者体内的WBC，无明显临床意义；喜炎平注射液治疗CAP患者有较好的疗效，且无严重不良反应，值得临床应用。
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关键词：喜炎平注射液；社区获得性肺炎；随机对照试验；Meta分析
中图分类号：R563.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.14.020
文章编号：1006-1959(2018)14-0064-06
Abstract：Objective To evaluate the clinical effect of Xiyanping injection in the treatment of adult community-acquired pneumonia.Methods A randomized controlled trial for the treatment of community-acquired pneumonia was published at home and abroad.Observed indicators included total clinical effectiveness，time to cough disappearance，time of disappearance of arpeggios，time to fever， white blood cell count，procalcitonin，and C-reactive protein.Results Finally，13 articles were included. Meta-analysis showed that the total effective rate was improved in the Xiyanping injection group compared with the control group：odds ratio was 4.24，95% confidence interva l2.93～6.14，P<0.00001；cough disappearance time)shortening：the weighted mean difference is -2.67，95CI：-3.91～-1.44，P<0.0001；the arpeggio disappearance time is shortened：the standardized mean difference is -0.91，95%CI：-1.16～-0.66，P<0.0001； The antipyretic time was shortened：WMD was -1.83，95% CI： -2.92～-0.74，P=0.001；WBC level showed no significant change：WMD was -1.14，95% CI：-2.77～0.48，P=0.17；PCT level reduction：SMD was -1.86，95%CI：-3.02～-0.70，P=0.002；CRP level decreased：SMD was -1.86，95% CI：-2.82～-0.89，P=0.0002.Conclusion The treatment of CAP with Xiyanping injection on the basis of routine western medicine treatment can significantly improve the total clinical effective rate，shorten the duration of cough，arpeggios，fever，and reduce the level of PCT，CRP in patients.However，there is no significant clinical significance in reducing WBC.The Xiyanping injection has better curative effect on CAP patients，and has no serious adverse reactions，so it is worthy of clinical application.
Key words：Xiyanping injection；Community-acquired pneumonia；Randomized controlled trial；Meta-analysis, 百拇医药(武珊珊)
, http://www.100md.com
关键词：喜炎平注射液；社区获得性肺炎；随机对照试验；Meta分析
中图分类号：R563.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.14.020
文章编号：1006-1959(2018)14-0064-06
Abstract：Objective To evaluate the clinical effect of Xiyanping injection in the treatment of adult community-acquired pneumonia.Methods A randomized controlled trial for the treatment of community-acquired pneumonia was published at home and abroad.Observed indicators included total clinical effectiveness，time to cough disappearance，time of disappearance of arpeggios，time to fever， white blood cell count，procalcitonin，and C-reactive protein.Results Finally，13 articles were included. Meta-analysis showed that the total effective rate was improved in the Xiyanping injection group compared with the control group：odds ratio was 4.24，95% confidence interva l2.93～6.14，P<0.00001；cough disappearance time)shortening：the weighted mean difference is -2.67，95CI：-3.91～-1.44，P<0.0001；the arpeggio disappearance time is shortened：the standardized mean difference is -0.91，95%CI：-1.16～-0.66，P<0.0001； The antipyretic time was shortened：WMD was -1.83，95% CI： -2.92～-0.74，P=0.001；WBC level showed no significant change：WMD was -1.14，95% CI：-2.77～0.48，P=0.17；PCT level reduction：SMD was -1.86，95%CI：-3.02～-0.70，P=0.002；CRP level decreased：SMD was -1.86，95% CI：-2.82～-0.89，P=0.0002.Conclusion The treatment of CAP with Xiyanping injection on the basis of routine western medicine treatment can significantly improve the total clinical effective rate，shorten the duration of cough，arpeggios，fever，and reduce the level of PCT，CRP in patients.However，there is no significant clinical significance in reducing WBC.The Xiyanping injection has better curative effect on CAP patients，and has no serious adverse reactions，so it is worthy of clinical application.
Key words：Xiyanping injection；Community-acquired pneumonia；Randomized controlled trial；Meta-analysis, 百拇医药(武珊珊)