阿托伐他汀改善蛛网膜下腔出血患者的预后分析(3)
总之,本研究显示阿托伐他汀对于蛛网膜下腔出血患者具有良好的耐受性。并且发现阿托伐他汀可以显著降低蛛网膜下腔出血患者血清中的一些炎症和内皮损伤因子,这些因子在SAH血管痉挛病理过程中发挥关键作用。阿托伐他汀可减少SAH血管痉挛的发生,减少TCD血流速度,降低参与血管痉挛的有害因子的产生。本试验研究显示阿托伐他汀对于蛛網膜下腔出血患者具有良好的耐受性,且可以明显减少SHA迟发型血管痉挛,进而减少其致残率及病死率,应该监测其肝损伤及肌损伤等副作用。
参考文献:
[1]Masato N,Akira M,Naoya M,et al.Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit[J].Translational Stroke Research,2013,4(3):368-374.
[2]Sehba FA,Hou J,Pluta RM,et al.The importance of early brain injury after subarachnoid hemorrhage[J].Progress in Neurobiology,2012,97(1):14-37.
[3]詹绍萍,刘辉,郁鹏,等.经颅多普勒超声诊断自发性蛛网膜下腔出血后脑血管痉挛[J].中华神经外科疾病研究杂志,2015,14(2):175-176.
[4]Kumar G,Shahripour RB,Harrigan MR.Vasospasm on transcranial Doppler is predictive of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage:a systematic review and meta-analysis[J].Journal of Neurosurgery,2016,124(5):1257-1264.
[5]Mrozek S,Dumurgier J,Citerio G,et al.Biomarkers and acute brain injuries: interest and limits[J].Critical Care,2014,18(2):220.
[6]杨位霞,毛蕾蕾,袁慧.蛛网膜下腔出血后迟发性脑血管痉挛的机制[J].中华行为医学与脑科学杂志, 2014(11):1048-1050.
[7]郝小可,史继新.蛛网膜下腔出血后早期脑损伤机制研究进展[J].医学研究生学报,2015,28(07):767-770.
收稿日期:2018-5-24;修回日期:2018-7-2
编辑/李桦, 百拇医药(王润俊)
参考文献:
[1]Masato N,Akira M,Naoya M,et al.Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit[J].Translational Stroke Research,2013,4(3):368-374.
[2]Sehba FA,Hou J,Pluta RM,et al.The importance of early brain injury after subarachnoid hemorrhage[J].Progress in Neurobiology,2012,97(1):14-37.
[3]詹绍萍,刘辉,郁鹏,等.经颅多普勒超声诊断自发性蛛网膜下腔出血后脑血管痉挛[J].中华神经外科疾病研究杂志,2015,14(2):175-176.
[4]Kumar G,Shahripour RB,Harrigan MR.Vasospasm on transcranial Doppler is predictive of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage:a systematic review and meta-analysis[J].Journal of Neurosurgery,2016,124(5):1257-1264.
[5]Mrozek S,Dumurgier J,Citerio G,et al.Biomarkers and acute brain injuries: interest and limits[J].Critical Care,2014,18(2):220.
[6]杨位霞,毛蕾蕾,袁慧.蛛网膜下腔出血后迟发性脑血管痉挛的机制[J].中华行为医学与脑科学杂志, 2014(11):1048-1050.
[7]郝小可,史继新.蛛网膜下腔出血后早期脑损伤机制研究进展[J].医学研究生学报,2015,28(07):767-770.
收稿日期:2018-5-24;修回日期:2018-7-2
编辑/李桦, 百拇医药(王润俊)