重组人干扰素α2b阴道泡腾胶囊治疗宫颈人乳头瘤病毒感染的临床研究(1)
摘 要：目的 研究重组人干扰素α2b阴道泡腾胶囊治疗宫颈人乳头瘤病毒感染的临床疗效。方法 选取我院2016年3月～2017年3月收治的96例HPV感染患者，采用随机数字表法将其分为实验组与参照组，各48例。实验组患者采用重组人干扰素α2b阴道泡腾胶囊治疗，参照组患者采用复方沙棘籽油栓治疗，对比两组患者的HPV转阴率、治疗有效率及HC2值，并观察不良反应。结果 实验组患者的HPV转阴率为87.23%，高于参照组的33.33%，差异具有统计学意义(P<0.05)。实验组患者的宫颈糜烂面治疗总有效率为91.67%，高于参照组的75.00%，差异具有统计学意义(P<0.05)。疗程结束1个月时，两组的HC2值比较，差异无统计学意义(P>0.05)；实验组患者在3个月、6个月后的HC2值低于参照组，差异具有统计学意义(P<0.05)。两组患者的不良反应比较，差异无统计学意义(P>0.05)。结论 应用重组人干扰素α2b阴道泡腾胶囊治疗HPV感染，对促使HPV转阴、缩小宫颈糜烂面均有积极作用，且不良反应少、安全性高。
关键词：重组人干扰素α2b阴道泡腾胶囊；HPV感染；不良反应
, 百拇医药
中图分类号：R711.74 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.14.045
文章编号：1006-1959(2018)14-0147-03
Abstract：Objective To study the clinical efficacy of recombinant human interferon α2b vaginal effervescent capsule in the treatment of human papillomavirus infection.Methods 96 patients with HPV infection who were admitted to our hospital from March 2016 to March 2017 were randomly divided into experimental group and reference group，48 cases each.Patients in the experimental group were treated with recombinant human interferon α2b vaginal effervescent capsule，and patients in the reference group were treated with compound seabuckthorn seed oil suppository.The HPV conversion rate，treatment efficiency and HC2 value were compared between the two groups，and adverse reactions were observed.Results The HPV conversion rate of the experimental group was 87.23%，which was higher than that of the reference group 33.33%，and the difference was statistically significant(P<0.05).The total effective rate of cervical erosion in the experimental group was 91.67%，which was higher than that in the reference group 75.00%， and the difference was statistically significant(P<0.05).1 months after the end of the course，the HC2 value of the two groups was not statistically significant(P>0.05).The HC2 value of the patients in the experimental group was lower than the reference group in 3 months and 6 months after the treatment，and the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The use of recombinant human interferon α2b vaginal effervescent capsule in the treatment of HPV infection has a positive effect on promoting HPV to negative and narrowing the cervical erosion surface，and has fewer adverse reactions and high safety.
, 百拇医药
Key words：Recombinant human interferon α2b vaginal effervescent capsule；HPV infection；Adverse reactions
宫颈人乳头瘤病毒(human papillomavirus，HPV)为球型DNA病毒，是一种乳多空病毒科的乳头瘤空泡病毒A属，会诱发人体皮皮肤黏膜的鳞状上皮增殖[1]。该病毒可通过性接触、母婴、医源性感染以及密切接触等途径进行传播[2]。女性宫颈HPV感染是宫颈癌的高危因素，近年来随着宫颈癌发病率的不断增长，临床中对HPV感染的治療也愈加重视。干扰素具有良好的抗病毒、抗增殖以及免疫调节作用，在治疗病毒感染性疾病中具有广泛应用。为探寻更为理想的宫颈HPV感染疗法，此次研究为患者采用重组人干扰素α2b阴道泡腾胶囊治疗，临床疗效显著，现报道如下。, http://www.100md.com(董艳)
关键词：重组人干扰素α2b阴道泡腾胶囊；HPV感染；不良反应
, 百拇医药
中图分类号：R711.74 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.14.045
文章编号：1006-1959(2018)14-0147-03
Abstract：Objective To study the clinical efficacy of recombinant human interferon α2b vaginal effervescent capsule in the treatment of human papillomavirus infection.Methods 96 patients with HPV infection who were admitted to our hospital from March 2016 to March 2017 were randomly divided into experimental group and reference group，48 cases each.Patients in the experimental group were treated with recombinant human interferon α2b vaginal effervescent capsule，and patients in the reference group were treated with compound seabuckthorn seed oil suppository.The HPV conversion rate，treatment efficiency and HC2 value were compared between the two groups，and adverse reactions were observed.Results The HPV conversion rate of the experimental group was 87.23%，which was higher than that of the reference group 33.33%，and the difference was statistically significant(P<0.05).The total effective rate of cervical erosion in the experimental group was 91.67%，which was higher than that in the reference group 75.00%， and the difference was statistically significant(P<0.05).1 months after the end of the course，the HC2 value of the two groups was not statistically significant(P>0.05).The HC2 value of the patients in the experimental group was lower than the reference group in 3 months and 6 months after the treatment，and the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The use of recombinant human interferon α2b vaginal effervescent capsule in the treatment of HPV infection has a positive effect on promoting HPV to negative and narrowing the cervical erosion surface，and has fewer adverse reactions and high safety.
, 百拇医药
Key words：Recombinant human interferon α2b vaginal effervescent capsule；HPV infection；Adverse reactions
宫颈人乳头瘤病毒(human papillomavirus，HPV)为球型DNA病毒，是一种乳多空病毒科的乳头瘤空泡病毒A属，会诱发人体皮皮肤黏膜的鳞状上皮增殖[1]。该病毒可通过性接触、母婴、医源性感染以及密切接触等途径进行传播[2]。女性宫颈HPV感染是宫颈癌的高危因素，近年来随着宫颈癌发病率的不断增长，临床中对HPV感染的治療也愈加重视。干扰素具有良好的抗病毒、抗增殖以及免疫调节作用，在治疗病毒感染性疾病中具有广泛应用。为探寻更为理想的宫颈HPV感染疗法，此次研究为患者采用重组人干扰素α2b阴道泡腾胶囊治疗，临床疗效显著，现报道如下。, http://www.100md.com(董艳)