茵陈蒿汤辅助治疗热重于湿型病毒性肝炎患者的效果研究(1)
摘 要：目的 研究茵陈蒿汤辅助治疗热重于湿型病毒性肝炎的临床效果。方法 选取我院2015年8月～2017年10月收治的80例热重于湿型病毒性肝炎患者，用1：1随机数字法分为对照组和研究组，每组40例。对照组接受西药治疗，研究组接受茵陈蒿汤治疗，观察两组患者治疗有效率、肝功能指标(PT、ALT、TBIL、AST)、并发症、病死率情况。结果 研究组治疗总有效率为92.50%，高于对照组的77.50%，差异具有统计学意义(P<0.05)。研究组肝功能指标均低于对照组，差异具有统计学意义(P<0.05)。研究组并发症发生率为12.50%，低于对照组的15.00%，但差异无统计学意义(P>0.05)。研究组病死率为7.50%，低于对照组的20.00%，差异具有统计学意义(P<0.05)。结论 茵陈蒿汤治疗热重于湿型病毒性肝炎，疗效突出，患者肝功能得到更为明显的改善，且安全性高。
关键词：热重于湿型；病毒性肝炎；茵陈蒿汤；肝功能
中图分类号：R259 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.14.048
, http://www.100md.com
文章编号：1006-1959(2018)14-0156-03
Abstract：Objective To study the clinical effect of Yinchenhao Decoction in the treatment of heat heavier than wet type viral hepatitis.Methods 80 patients with heat heavier than wet type viral hepatitis admitted to our hospital from August 2015 to October 2017 were enrolled.The patients were divided into the control group and the study group by 1：1 random number method，40 cases in each group.The control group received western medicine treatment.The study group received Yinchenhao Decoction.The treatment efficiency，liver function indexes(PT，ALT，TBIL，AST)，complications and mortality were observed.Results The total effective rate of the study group was 92.50%， which was higher than 77.50% of the control group，the difference was statistically significant(P<0.05).The liver function indexes of the study group were lower than the control group，and the difference was statistically significant (P<0.05).The complication rate of the study group was 12.50%，which was lower than that of the control group 15.00%，but the difference was not statistically significant(P>0.05).The mortality rate of the study group was 7.50%，which was lower than that of the control group 20.00%，the difference was statistically significant(P<0.05).Conclusion Yinchenhao Decoction is effective in treating viral hepatitis with heat heavier than wet type.The liver function of patients is obviously improved，and the safety is high.
, 百拇医药
Key words：Heat heavier than wet type；Viral hepatitis；Yinchenhao Decoction；Liver function
病毒性肝炎(viral hepatitis)指人體感染肝炎病毒后出现免疫反应，导致肝细胞发生坏死、水肿、变性等。部分轻型急性肝炎患者可自愈，但若感染较强毒力的病毒，剧烈性免疫反应会引发肝衰竭、重型肝炎，若反复发作、迁延不愈，容易发展成慢性肝炎，甚至肝硬化和肝细胞癌[1]。因此，临床早期给予有效干预相当重要。近年来，西药治疗病毒性肝炎疾病虽有一定疗效，但不良反应多、易反复。中医认为此疾病为“鼓胀、胁痛、黄疸”范围，较为常见的一个类型则为热重于湿型。茵陈蒿汤具有退黄、利湿、清热的功效，多用于治疗湿热型黄疸。而将其用于西药治疗基础上治疗病毒性肝炎疾病，安全可靠，疗效突出，得到了临床支持和验证，但仍有部分学者对此存在争议。为此，本研究纳入80例患者分两组讨论茵陈蒿汤治疗价值，具体报告如下。
1资料与方法
1.1一般资料 选取佳木斯市中医医院2015年8月～2017年10月收治的80例热重于湿型病毒性肝炎患者，本研究经医院伦理会批准。采用1：1随机数字法将患者分为对照组和研究组，每组40例。对照组男性22例，女性18例，年龄23～65岁，平均年龄(44.25±2.56)岁，病程11～32个月，平均病程(25.84±5.25)个月；疾病程度：29例轻度，11例中度。研究组男性23例，女性17例，年龄23～66岁，平均年龄(44.35±2.43)岁，病程11～31个月，平均病程(25.93±5.14)个月；疾病程度：30例轻度，10例中度。两组患者性别、年龄、病程等基本资料比较，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(刘钰书)
关键词：热重于湿型；病毒性肝炎；茵陈蒿汤；肝功能
中图分类号：R259 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.14.048
, http://www.100md.com
文章编号：1006-1959(2018)14-0156-03
Abstract：Objective To study the clinical effect of Yinchenhao Decoction in the treatment of heat heavier than wet type viral hepatitis.Methods 80 patients with heat heavier than wet type viral hepatitis admitted to our hospital from August 2015 to October 2017 were enrolled.The patients were divided into the control group and the study group by 1：1 random number method，40 cases in each group.The control group received western medicine treatment.The study group received Yinchenhao Decoction.The treatment efficiency，liver function indexes(PT，ALT，TBIL，AST)，complications and mortality were observed.Results The total effective rate of the study group was 92.50%， which was higher than 77.50% of the control group，the difference was statistically significant(P<0.05).The liver function indexes of the study group were lower than the control group，and the difference was statistically significant (P<0.05).The complication rate of the study group was 12.50%，which was lower than that of the control group 15.00%，but the difference was not statistically significant(P>0.05).The mortality rate of the study group was 7.50%，which was lower than that of the control group 20.00%，the difference was statistically significant(P<0.05).Conclusion Yinchenhao Decoction is effective in treating viral hepatitis with heat heavier than wet type.The liver function of patients is obviously improved，and the safety is high.
, 百拇医药
Key words：Heat heavier than wet type；Viral hepatitis；Yinchenhao Decoction；Liver function
病毒性肝炎(viral hepatitis)指人體感染肝炎病毒后出现免疫反应，导致肝细胞发生坏死、水肿、变性等。部分轻型急性肝炎患者可自愈，但若感染较强毒力的病毒，剧烈性免疫反应会引发肝衰竭、重型肝炎，若反复发作、迁延不愈，容易发展成慢性肝炎，甚至肝硬化和肝细胞癌[1]。因此，临床早期给予有效干预相当重要。近年来，西药治疗病毒性肝炎疾病虽有一定疗效，但不良反应多、易反复。中医认为此疾病为“鼓胀、胁痛、黄疸”范围，较为常见的一个类型则为热重于湿型。茵陈蒿汤具有退黄、利湿、清热的功效，多用于治疗湿热型黄疸。而将其用于西药治疗基础上治疗病毒性肝炎疾病，安全可靠，疗效突出，得到了临床支持和验证，但仍有部分学者对此存在争议。为此，本研究纳入80例患者分两组讨论茵陈蒿汤治疗价值，具体报告如下。
1资料与方法
1.1一般资料 选取佳木斯市中医医院2015年8月～2017年10月收治的80例热重于湿型病毒性肝炎患者，本研究经医院伦理会批准。采用1：1随机数字法将患者分为对照组和研究组，每组40例。对照组男性22例，女性18例，年龄23～65岁，平均年龄(44.25±2.56)岁，病程11～32个月，平均病程(25.84±5.25)个月；疾病程度：29例轻度，11例中度。研究组男性23例，女性17例，年龄23～66岁，平均年龄(44.35±2.43)岁，病程11～31个月，平均病程(25.93±5.14)个月；疾病程度：30例轻度，10例中度。两组患者性别、年龄、病程等基本资料比较，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(刘钰书)