血浆NT—proBNP水平与同型半胱氨酸对糖尿病合并心房颤动的相关性研究(1)

http://www.100md.com 2018年4月9日 《医学信息》 2018年第14期

     摘 要：目的 探讨2型糖尿病合并心房颤动患者血N末端B型利钠肽原水平与同型半胱氨酸相关性。方法 选取2016年1月～2017年1月在我院接受治疗的T2DM患者120例，根据其有无心房颤动将患者分为房颤组(48例)和无房颤组(72例)，所有患者均采用全自动生化分析仪检测血浆NT-proBNP及Hcy的水检测，观察两组血浆NT-proBNP水平與同型半胱氨酸的相关性。结果 观察组血浆NT-proBNP、Hcy均高于对照组，差异有统计学意义(P<0.05)；观察组血浆NT-proBNP水平与Hcy呈正相关(r=0.328，P<0.05)；两组间LAD、LVDD、LVEF、糖尿病病程相比较，差异无统计学意义(P>0.05)。房颤组血浆NT-proBNP水平、Hcy高于无房颤组，差异有统计学意义(P<0.05)，血浆NT-proBNP水平与Hcy呈正相关(r=0.328，P<0.05)。结论血浆NT-proBNP、Hcy为糖尿病并发房颤的危险因素。可通过联合检测血浆NT-proBNP及Hcy的水平预知糖尿病发生房颤的可能。

    关键词：糖尿病；心房颤动；血浆NT-proBNP；同型半胱氨酸

    中图分类号：R587.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.14.053

    文章编号：1006-1959(2018)14-0169-03

    Abstract：Objective To investigate the relationship between plasma N-terminal type B natriuretic peptide and homocysteine in patients with type 2 diabetes mellitus complicated with atrial fibrillation.Methods 120 patients with T2DM who were treated in our hospital from January 2016 to January 2017 were selected.Patients were divided into atrial fibrillation group(n=48)and non-atrial fibrillation group(n=72)according to their presence or absence of atrial fibrillation.The plasma NT-proBNP and Hcy were detected by automatic biochemical analyzer，and the correlation between plasma NT-proBNP and homocysteine was observed.Results The plasma NT-proBNP and Hcy levels in the observation group were significantly higher than those in the control group，the difference was statistically significant(P<0.05)，the plasma NT-proBNP level in the observation group was positively correlated with Hcy(r=0.328，P< 0.05)，there was no significant difference in the duration of LAD，LVDD，LVEF and diabetes between the two groups(P>0.05).The plasma NT-proBNP level and Hcy in the atrial fibrillation group were higher than those in the non atrial fibrillation group，the difference was statistically significant(P<0.05)，and the plasma NT-proBNP level was positively correlated with Hcy(r=0.328，P<0.05). Conclusion Plasma NT-proBNP and Hcy are risk factors for diabetes mellitus complicated with atrial fibrillation.The possibility of atrial fibrillation in diabetes can be predicted by combined detection of plasma NT-proBNP and Hcy levels.

    Key words：Diabetes mellitus；Atrial fibrillation；Plasma NT-proBNP；Homocysteine

    心房颤动(atrial fibrillation，AF)是最常见的心律失常之一，可增加脑卒中和死亡的发生风险[1]。NT-proBNP又称N末端B型利钠肽原，是心室肌细胞分泌B型钠利尿肽时产生的一种神经激素，在临床中大多通过检测NT-proBNP来反映血浆BNP的水平。NT-proBNP为诊断及判断心力衰竭预后的标志物[2]。而近期有研究显示即使在没有心衰的情况下，大多数心房颤动患者的NT-proBNP显著升高。在心房颤动患者中，NT-proBNP的浓度与心脏心室的重构有关[3]。目前关于2型糖尿病并发心房颤动患者血浆NT-proBNP研究甚少，而与同型半胱氨酸(Hcy)相关性研究更是少有报道。本文回顾性的研究了2型糖尿病合并房颤患者血NT-proBNP水平与Hcy的相关性，现报道如下。(王淑娟 林祥灿)

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