顺铂注射液联合卡铂注射液对喉癌患者临床疗效的研究(1)
摘 要：目的 观察顺铂注射液联合卡铂注射液在喉癌患者中的临床疗效。方法 选择2017年4月～2018年1月入院治疗的喉癌患者110例，采用随机数字法分为对照组和观察组，每组55例。对照组采用顺铂注射液治疗，观察组采用顺铂注射液联合卡铂注射液治疗，两组均连续治疗4个疗程，治疗后对两组患者有效率、毒副反应发生率进行评估。结果 观察组顺铂注射液联合卡铂注射液治疗4个疗程疗效率为38.18%，高于对照组23.64%，差异有统计学意义(P<0.05);治疗4个疗程后，观察组恶心呕吐、白细胞下降、腹泻、发热、神经毒性及皮疹发生率与对照组相比，差异无统计学意义(P>0.05)。结论 顺铂注射液联合卡铂注射液用于喉癌患者能提高临床疗效，未增加毒副反应发生率。
关键词：顺铂注射液;卡铂注射液;喉癌;毒副反应
中图分类号： R739.65 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.16.027
, 百拇医药
文章編号：1006-1959(2018)16-0092-03
Clinical Efficacy of Cisplatin Combined with Carboplatin in Patients with Laryngeal Cancer
ZHANG Yi-ying，SONG Guang-bin
(Department of ENT，Stomatological Hospital Affiliated to Jiamusi University，Jiamusi 154003，Heilongjiang，China)
Abstract：Objective To observe the clinical efficacy of Cisplatin injection combined with Carboplatin injection in patients with laryngeal cancer.Methods A total of 110 patients with laryngeal cancer who were admitted to hospital from April 2017 to January 2018 were randomly divided into the control group and the observation group，with 55 cases in each group.The control group was treated with cisplatin injection.The observation group was treated with cisplatin injection combined with carboplatin injection.The two groups were treated continuously for 4 courses，after treatment，the effective rate and incidence of toxic side effects were evaluated. Results The therapeutic effect of cisplatin injection combined with carboplatin injection was 38.18%，which was higher than that of the control group 23.64%，the difference was statistically significant(P<0.05).After 4 courses of treatment，the incidence of nausea and vomiting，leukopenia，diarrhea，fever，neurotoxicity and rash in the observation group was not significantly different from that in the control group(P>0.05).Conclusion Cisplatin injection combined with Carboplatin injection can improve the clinical efficacy of laryngeal cancer patients without increasing the incidence of toxic and side effects.
, 百拇医药
Key words：Cisplatin injection;Carboplatin injection;Laryngeal cancer;Toxic side effects
喉癌(laryngeal cancer)分为原发性喉癌与继发性喉癌两种。原发性喉癌是指原发部位位于喉部的肿瘤，多以鳞状细胞癌为主;而继发性喉癌则是指来自其他部位的恶性肿瘤，临床上相对少见[1]。患者发病后临床表现为声嘶、呼吸困难、咳嗽及吞咽困难等，影响患者健康及生活。同时，由于早期喉癌发病早期临床症状缺乏特异性，多数患者一旦确诊，已经是中、晚期，丧失了最佳治疗时机。手术治疗是喉癌患者中常用的治疗方法，能切除病灶组织，延长患者寿命，但是手术具有一定的风险性、创伤性，破坏喉结构的完整性，导致部分患者术后丧失喉功能。本研究以2017年4月～2018年1月入院治疗的喉癌患者110例，探讨顺铂注射液联合卡铂注射液在喉癌患者中的疗效观察及对毒副反应发生率的影响，现报道如下。, 百拇医药(张艺莹 宋广斌)
关键词：顺铂注射液;卡铂注射液;喉癌;毒副反应
中图分类号： R739.65 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.16.027
, 百拇医药
文章編号：1006-1959(2018)16-0092-03
Clinical Efficacy of Cisplatin Combined with Carboplatin in Patients with Laryngeal Cancer
ZHANG Yi-ying，SONG Guang-bin
(Department of ENT，Stomatological Hospital Affiliated to Jiamusi University，Jiamusi 154003，Heilongjiang，China)
Abstract：Objective To observe the clinical efficacy of Cisplatin injection combined with Carboplatin injection in patients with laryngeal cancer.Methods A total of 110 patients with laryngeal cancer who were admitted to hospital from April 2017 to January 2018 were randomly divided into the control group and the observation group，with 55 cases in each group.The control group was treated with cisplatin injection.The observation group was treated with cisplatin injection combined with carboplatin injection.The two groups were treated continuously for 4 courses，after treatment，the effective rate and incidence of toxic side effects were evaluated. Results The therapeutic effect of cisplatin injection combined with carboplatin injection was 38.18%，which was higher than that of the control group 23.64%，the difference was statistically significant(P<0.05).After 4 courses of treatment，the incidence of nausea and vomiting，leukopenia，diarrhea，fever，neurotoxicity and rash in the observation group was not significantly different from that in the control group(P>0.05).Conclusion Cisplatin injection combined with Carboplatin injection can improve the clinical efficacy of laryngeal cancer patients without increasing the incidence of toxic and side effects.
, 百拇医药
Key words：Cisplatin injection;Carboplatin injection;Laryngeal cancer;Toxic side effects
喉癌(laryngeal cancer)分为原发性喉癌与继发性喉癌两种。原发性喉癌是指原发部位位于喉部的肿瘤，多以鳞状细胞癌为主;而继发性喉癌则是指来自其他部位的恶性肿瘤，临床上相对少见[1]。患者发病后临床表现为声嘶、呼吸困难、咳嗽及吞咽困难等，影响患者健康及生活。同时，由于早期喉癌发病早期临床症状缺乏特异性，多数患者一旦确诊，已经是中、晚期，丧失了最佳治疗时机。手术治疗是喉癌患者中常用的治疗方法，能切除病灶组织，延长患者寿命，但是手术具有一定的风险性、创伤性，破坏喉结构的完整性，导致部分患者术后丧失喉功能。本研究以2017年4月～2018年1月入院治疗的喉癌患者110例，探讨顺铂注射液联合卡铂注射液在喉癌患者中的疗效观察及对毒副反应发生率的影响，现报道如下。, 百拇医药(张艺莹 宋广斌)