妊娠期人巨细胞病毒感染的中医药研究进展(1)
摘要：妊娠期人巨细胞病毒感染宫内传播可导致流产、胎儿生长受限、小头畸形及子代出生后渐进性感音神经性耳聋、认识障碍等严重并发症，严重危害母儿健康。西药治疗妊娠期人巨细胞病毒感染存在致畸、耐药等风险，目前尚未建立理想的对妊娠期活动性巨细胞病毒感染一级预防方案。在中医古籍中，该病病因病机多与“毒”“虚”“湿热”密切相关。中医药治疗妊娠期巨细胞病毒感染有肯定的疗效，安全性高，本文对目前妊娠期巨细胞病毒感染的中医药治疗理论基础、治疗方案进行了总结。
关键词：人巨细胞病毒;妊娠;中医药;病因病机
中图分类号：R259 文獻标识码：A DOI：10.3969/j.issn.1006-1959.2019.01.013
文章编号：1006-1959(2019)01-0037-04
, 百拇医药
Advances in Research on Traditional Chinese Medicine for Human Cytomegalovirus Infection during Pregnancy
LI Wei，CHEN Su-hua
(Department of Obstetrics and Gynecology，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Hubei，China)
Abstract：Intrauterine transmission of human cytomegalovirus infection during pregnancy can lead to abortion， fetal growth restriction， microcephaly and progressive complications such as progressive deafness and neurological deafness after birth， and cognitive impairment， which seriously endangers maternal and child health. Western medicine for the treatment of human cytomegalovirus infection during pregnancy is teratogenic， drug-resistant and other risks， and has not yet established an ideal primary prevention program for active cytomegalovirus infection during pregnancy. In the ancient books of traditional Chinese medicine， the pathogenesis of the disease is closely related to "poison"， "virtual" and "damp heat". Traditional Chinese medicine has a positive effect on the treatment of gestational cytomegalovirus infection， and it has high safety. This paper summarizes the theoretical basis and treatment plan of traditional Chinese medicine treatment for gestational cytomegalovirus infection.
, 百拇医药
Key words：Human cytomegalovirus;Pregnancy;Traditional Chinese medicine;Etiology and pathogenesis
人巨细胞病毒(human cytomegalovirus，HCMV)是全世界尤其是发展中国家最常见的机会感染病原体[1，2]。妊娠期CMV感染可宫内传播导致流产、胎儿生长受限及出生后感觉神经性耳聋、视力障碍、神经功能缺陷、学习障碍等后遗症[3-6]，严重危害母儿健康。CMV疫苗漫长且艰难，目前对妊娠期活动性HCMV感染缺乏有效的一级预防方案，更昔洛韦等抗病毒西药虽广泛应用于器官移植、HIV患者合并的HCMV感染中，但其明确的胎儿致畸作用限制了在妊娠期中的应用[7-9]。中医药对治疗妊娠期巨细胞病毒感染安全性高，副作用小，患者依从性高，得到了广泛应用[10-12]。本文对于妊娠期巨细胞病毒感染的病因病机和治疗进展进行了初步的综述，为建立妊娠期人巨细胞病毒中医药治疗体系奠定基础。
1中医学对该病的认识
中医主要是从宏观的角度，用哲学的方法，从整体上对生命和疾病进行研究。巨细胞病毒宫内感染是一个西医学概念，中医并无巨细胞病毒宫内感染的病名，但根据其发病特征及临床表现当属中医“胎动不安，胎漏，胎萎不长，小产，滑胎，热入血室，儿科解颅，胎黄”等范畴。关于此类疾病在我国古代医学古籍书中多有记载，总结其病因病机多与“毒”“虚”“湿热”密切相关。, 百拇医药(李伟 陈素华)
关键词：人巨细胞病毒;妊娠;中医药;病因病机
中图分类号：R259 文獻标识码：A DOI：10.3969/j.issn.1006-1959.2019.01.013
文章编号：1006-1959(2019)01-0037-04
, 百拇医药
Advances in Research on Traditional Chinese Medicine for Human Cytomegalovirus Infection during Pregnancy
LI Wei，CHEN Su-hua
(Department of Obstetrics and Gynecology，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Hubei，China)
Abstract：Intrauterine transmission of human cytomegalovirus infection during pregnancy can lead to abortion， fetal growth restriction， microcephaly and progressive complications such as progressive deafness and neurological deafness after birth， and cognitive impairment， which seriously endangers maternal and child health. Western medicine for the treatment of human cytomegalovirus infection during pregnancy is teratogenic， drug-resistant and other risks， and has not yet established an ideal primary prevention program for active cytomegalovirus infection during pregnancy. In the ancient books of traditional Chinese medicine， the pathogenesis of the disease is closely related to "poison"， "virtual" and "damp heat". Traditional Chinese medicine has a positive effect on the treatment of gestational cytomegalovirus infection， and it has high safety. This paper summarizes the theoretical basis and treatment plan of traditional Chinese medicine treatment for gestational cytomegalovirus infection.
, 百拇医药
Key words：Human cytomegalovirus;Pregnancy;Traditional Chinese medicine;Etiology and pathogenesis
人巨细胞病毒(human cytomegalovirus，HCMV)是全世界尤其是发展中国家最常见的机会感染病原体[1，2]。妊娠期CMV感染可宫内传播导致流产、胎儿生长受限及出生后感觉神经性耳聋、视力障碍、神经功能缺陷、学习障碍等后遗症[3-6]，严重危害母儿健康。CMV疫苗漫长且艰难，目前对妊娠期活动性HCMV感染缺乏有效的一级预防方案，更昔洛韦等抗病毒西药虽广泛应用于器官移植、HIV患者合并的HCMV感染中，但其明确的胎儿致畸作用限制了在妊娠期中的应用[7-9]。中医药对治疗妊娠期巨细胞病毒感染安全性高，副作用小，患者依从性高，得到了广泛应用[10-12]。本文对于妊娠期巨细胞病毒感染的病因病机和治疗进展进行了初步的综述，为建立妊娠期人巨细胞病毒中医药治疗体系奠定基础。
1中医学对该病的认识
中医主要是从宏观的角度，用哲学的方法，从整体上对生命和疾病进行研究。巨细胞病毒宫内感染是一个西医学概念，中医并无巨细胞病毒宫内感染的病名，但根据其发病特征及临床表现当属中医“胎动不安，胎漏，胎萎不长，小产，滑胎，热入血室，儿科解颅，胎黄”等范畴。关于此类疾病在我国古代医学古籍书中多有记载，总结其病因病机多与“毒”“虚”“湿热”密切相关。, 百拇医药(李伟 陈素华)