皮肤AGEs荧光检测对糖尿病肾病的临床意义(1)
摘要：目的 探討皮肤AGEs荧光检测对糖尿病肾病的早期诊断价值及与糖尿病肾病分期相关性的临床意义。方法 将我院住院的122例糖尿病患者按尿白蛋白/肌酐比值，眼底检查及CKD分期分为单纯糖尿病组(DM0组)42例、糖尿病肾病eGFR≥45 ml/(min·1.73 m2)组(DKD1组)49例和糖尿病肾病eGFR<45 ml/(min/1.73·m2)组(DKD2组)31例，选取同期行肾穿刺肾功能正常的非糖尿病患者51例为对照组(NC组)，分别检测各组皮肤AGEs、血白蛋白、尿微量白蛋白等指标。结果 ①糖尿病患者的皮肤AGEs、SBP、SCr、TG、TC均高于对照组，ALB、HB低于对照组，差异均有统计学意义(P<0.05);②与DMO组比较，DKD1组和DKD2组的SBP、肌酐、UA、24hUP、尿微量白蛋白、皮肤AGEs水平均升高，且DKD2组高于DKD1组，差异有统计学意义(P<0.05);而TP、ALB、HB水平均降低，且DKD2组低于DKD1组，差异有统计学意义(P<0.05);③糖尿病患者皮肤AGEs水平与尿微量白蛋白水平呈正相关(r=0.484，P<0.05)。④皮肤AGEs是糖尿病肾病相关的危险因素[OR=1.113，95%CI(1.055，1.174)]。⑤ROC曲线分析显示皮肤AGEs检测糖尿病肾病的敏感性为68.75%，特异性为71.43%。结论 AGEs可能参与糖尿病肾病发生发展，荧光检测皮肤AGEs可用于早期筛查DKD并且评估其病变程度。
, http://www.100md.com
关键词：糖尿病肾病;糖尿病;糖基化终产物;荧光光谱法;皮肤
中图分类号：R587.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.06.031
文章编号：1006-1959(2019)06-0101-04
Abstract：Objective To investigate the value of skin AGEs fluorescence detection in early diagnosis of diabetic kidney disease and its clinical significance in relation to staging of diabetic kidney disease.Methods The 122 patients with diabetes admitted to our hospital were divided into urinary albumin/creatinine ratio， fundus examination and CKD staging into 42 patients with diabetes alone (DM0 group) and diabetic kidney disease with eGFR ≥ 45 ml/(min·1.73 m2) group (DKD1). Group of 49 patients with diabetic kidney disease eGFR<45 ml/(min/1.73·m2) group (DKD2 group) 31 cases， 51 cases of non-diabetic patients with normal renal renal function were selected as control group (NC group)， respectively the indicators of skin AGEs， serum albumin， and urine microalbumin were measured. Results ①The skin AGEs， SBP， SCr， TG and TC of diabetic patients were higher than the control group， and the ALB and HB were lower than the control group， the difference was statistically significant (P<0.05). ②Compared with DMO group， SBP， creatinine， UA， 24hUP， urinary albumin and AGEs of DKD1 group and DKD2 group were increased， and DKD2 group was higher than DKD1 group， the difference was statistically significant (P<0.05). The TP， ALB， and HB levels were lower， and the DKD2 group was lower than the DKD1 group，the difference was statistically significant (P<0.05).③The level of skin AGEs in diabetic patients was positively correlated with urinary microalbumin (r=0.484， P<0.05).④Skin AGEs are risk factors associated with diabetic kidney disease [OR=1.113， 95% CI (1.055， 1.174)].⑤ROC curve analysis showed that the sensitivity of skin AGEs to detect diabetic kidney disease was 68.75% and the specificity was 71.43%. Conclusion AGEs may be involved in the development of diabetic kidney disease.Fluorescence detection of skin AGEs can be used to screen DKD early and assess the extent of the disease., 百拇医药(吴怡琪 卢文)
, http://www.100md.com
关键词：糖尿病肾病;糖尿病;糖基化终产物;荧光光谱法;皮肤
中图分类号：R587.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.06.031
文章编号：1006-1959(2019)06-0101-04
Abstract：Objective To investigate the value of skin AGEs fluorescence detection in early diagnosis of diabetic kidney disease and its clinical significance in relation to staging of diabetic kidney disease.Methods The 122 patients with diabetes admitted to our hospital were divided into urinary albumin/creatinine ratio， fundus examination and CKD staging into 42 patients with diabetes alone (DM0 group) and diabetic kidney disease with eGFR ≥ 45 ml/(min·1.73 m2) group (DKD1). Group of 49 patients with diabetic kidney disease eGFR<45 ml/(min/1.73·m2) group (DKD2 group) 31 cases， 51 cases of non-diabetic patients with normal renal renal function were selected as control group (NC group)， respectively the indicators of skin AGEs， serum albumin， and urine microalbumin were measured. Results ①The skin AGEs， SBP， SCr， TG and TC of diabetic patients were higher than the control group， and the ALB and HB were lower than the control group， the difference was statistically significant (P<0.05). ②Compared with DMO group， SBP， creatinine， UA， 24hUP， urinary albumin and AGEs of DKD1 group and DKD2 group were increased， and DKD2 group was higher than DKD1 group， the difference was statistically significant (P<0.05). The TP， ALB， and HB levels were lower， and the DKD2 group was lower than the DKD1 group，the difference was statistically significant (P<0.05).③The level of skin AGEs in diabetic patients was positively correlated with urinary microalbumin (r=0.484， P<0.05).④Skin AGEs are risk factors associated with diabetic kidney disease [OR=1.113， 95% CI (1.055， 1.174)].⑤ROC curve analysis showed that the sensitivity of skin AGEs to detect diabetic kidney disease was 68.75% and the specificity was 71.43%. Conclusion AGEs may be involved in the development of diabetic kidney disease.Fluorescence detection of skin AGEs can be used to screen DKD early and assess the extent of the disease., 百拇医药(吴怡琪 卢文)