不同剂量文拉法辛与阿戈美拉汀治疗难治性抑郁症的疗效分析(1)
摘要：目的 研究不同剂量文拉法辛与阿戈美拉汀治疗难治性抑郁症的疗效。方法 选取2017年6月～2018年8月我院收治的难治性抑郁症患者236例，随机分为观察组和对照组，每组118例。观察组采用大剂量文拉法辛与阿戈美拉汀治疗，对照组采用小剂量文拉法辛与阿戈美拉汀治疗，6周为1疗程，共治疗1个疗程。分析两组不同时间段(治疗2周、4周、6周末)HAMD-17评分和不良反应。结果 观察组治疗后2、4、6周HAMD-17评分分别为(17.21±1.02)分、(14.22±1.34)分、(10.03±1.21)分，均低于对照组的(21.64±1.57)分、(16.98±1.76)分、(13.88±1.97)分，差异具有统计学意义(P<0.05)。观察组不良反应发生率为1.69%，与对照组的2.54%比较，差异无统计学意义(P>0.05)。结论 使用大剂量文拉法辛与阿戈美拉汀治疗难治性抑郁症，疗效显著，不仅能够改善患者抑郁症状，且具有极高安全性。
关键词：文拉法辛;阿戈美拉汀;难治性抑郁症
, http://www.100md.com
中图分类号：R749.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.07.048
文章编号：1006-1959(2019)07-0155-03
Abstract：Objective To study the efficacy of different doses of venlafaxine and agomelatine in the treatment of refractory depression. Methods A total of 236 patients with refractory depression admitted to our hospital from June 2017 to August 2018 were randomly divided into observation group and control group， with 118 cases in each group. The observation group was treated with high-dose venlafaxine and agomelatine. The control group was treated with low-dose venlafaxine and agomelatine， and 6 weeks was a course of treatment for a total of 1 course of treatment. The HAMD-17 score and adverse reactions were analyzed at different time periods (2 weeks， 4 weeks， 6 weeks of treatment). Results The HAMD-17 scores of the observation group at 2， 4， and 6 weeks after treatment were (17.21±1.02)， (14.22±1.34)， and (10.03±1.21)， respectively， which were lower than those of the control group (21.64±1.57). (16.98±1.76) and (13.88±1.97) points， the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 1.69%， compared with 2.54% in the control group， the difference was not statistically significant (P>0.05). Conclusion The use of high-dose venlafaxine and agomelatine in the treatment of refractory depression has a significant effect， which not only improves the patient's depressive symptoms， but also has a high safety.
, 百拇医药
Key words：different doses; venlafaxine; agomelatine; treatment; refractory depression
難治性抑郁症(treatment-resistant depression，TRD)主要是指抑郁症患者应以2种或以上不同治疗机制和不同性能的药物进行足疗程、足量的治疗，其效果不佳或效果甚微。据资料显示，在我国全部抑郁患者中，难治性抑郁症占比约为20%[1]。目前临床对于该疾病通常以药物治疗为主，文拉法辛为治疗抑郁症的常用药物，其具有独特的药效、药代动力学和精神药理，能够起到显著的抗抑郁作用。但有研究表明，不同剂量的药物对疾病可产生不同疗效，而选择适宜的剂量治疗为临床广泛讨论的话题[2]。本研究选取我院收治的236例难治性抑郁症患者进行分析，现报道如下。, 百拇医药(张自萍)
关键词：文拉法辛;阿戈美拉汀;难治性抑郁症
, http://www.100md.com
中图分类号：R749.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.07.048
文章编号：1006-1959(2019)07-0155-03
Abstract：Objective To study the efficacy of different doses of venlafaxine and agomelatine in the treatment of refractory depression. Methods A total of 236 patients with refractory depression admitted to our hospital from June 2017 to August 2018 were randomly divided into observation group and control group， with 118 cases in each group. The observation group was treated with high-dose venlafaxine and agomelatine. The control group was treated with low-dose venlafaxine and agomelatine， and 6 weeks was a course of treatment for a total of 1 course of treatment. The HAMD-17 score and adverse reactions were analyzed at different time periods (2 weeks， 4 weeks， 6 weeks of treatment). Results The HAMD-17 scores of the observation group at 2， 4， and 6 weeks after treatment were (17.21±1.02)， (14.22±1.34)， and (10.03±1.21)， respectively， which were lower than those of the control group (21.64±1.57). (16.98±1.76) and (13.88±1.97) points， the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 1.69%， compared with 2.54% in the control group， the difference was not statistically significant (P>0.05). Conclusion The use of high-dose venlafaxine and agomelatine in the treatment of refractory depression has a significant effect， which not only improves the patient's depressive symptoms， but also has a high safety.
, 百拇医药
Key words：different doses; venlafaxine; agomelatine; treatment; refractory depression
難治性抑郁症(treatment-resistant depression，TRD)主要是指抑郁症患者应以2种或以上不同治疗机制和不同性能的药物进行足疗程、足量的治疗，其效果不佳或效果甚微。据资料显示，在我国全部抑郁患者中，难治性抑郁症占比约为20%[1]。目前临床对于该疾病通常以药物治疗为主，文拉法辛为治疗抑郁症的常用药物，其具有独特的药效、药代动力学和精神药理，能够起到显著的抗抑郁作用。但有研究表明，不同剂量的药物对疾病可产生不同疗效，而选择适宜的剂量治疗为临床广泛讨论的话题[2]。本研究选取我院收治的236例难治性抑郁症患者进行分析，现报道如下。, 百拇医药(张自萍)