阿奇霉素治疗急性细菌性下呼吸道感染的有效性和安全性评价(1)
摘要：目的 对本院急性细菌性下呼吸道感染患者运用阿奇霉素治疗，分析其有效性和安全性。方法 回顾性分析2016年6月～2018年6月我院收治的96例急性细菌性下呼吸道感染患者临床资料，随机分为两组，其中实验组患者为48例，采用阿奇霉素治疗;对照组48例患者采用左氧氟沙星治疗，比较两组患者的临床疗效，临床症状持续时间以及不良反应发生情况。结果 实验组治疗总有效率(95.83%)高于对照组(70.83%)，差异具有统计学意义(P<0.05);实验组肺啰音、发热、咳嗽症状持续时间均短于对照组，差异具有统计学意义(P<0.05);实验组不良反应发生率低于对照组(P<0.05)。结论 采用阿奇霉素治疗急性细菌性下呼吸道感染疗效确切，不良反应少，是临床上治疗急性细菌性下呼吸道感染安全性抗生素之一。
关键词：阿奇霉素;急性细菌性下呼吸道感染;左氧氟沙星
中图分类号：R56 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.11.045
, http://www.100md.com
文章编号：1006-1959(2019)11-0152-02
Abstract：Objective To analyze the efficacy and safety of azithromycin in patients with acute bacterial lower respiratory tract infection in our hospital.Methods The clinical data of 96 patients with acute bacterial lower respiratory tract infection admitted to our hospital from June 2016 to June 2018 were retrospectively analyzed. They were randomly divided into two groups， including 48 patients in the experimental group and treated with azithromycin，48 patients in the control group were treated with levofloxacin， and the clinical efficacy， duration of clinical symptoms， and adverse reactions were compared between the two groups.Results The total effective rate of the experimental group (95.83%) was higher than that of the control group (70.83%)，the difference was statistically significant (P<0.05). The duration of pulmonary snoring， fever and cough in the experimental group was shorter than that of the control group，the difference was statistically significant(P<0.05);the incidence of adverse reactions in the experimental group was lower than that in the control group(P<0.05).Conclusion Azithromycin is effective in the treatment of acute bacterial lower respiratory tract infections with few adverse reactions. It is one of the safe antibiotics for the treatment of acute bacterial lower respiratory tract infections.
, 百拇医药
Key words：Azithromycin;Acute bacterial lower respiratory tract infection;Levofloxacin
急性細菌性下呼吸道感染(acute bacterial lower respiratory tract infection)是临床呼吸道感染常见病，不仅多发于儿童，而且也是慢性阻塞性肺炎(COPD)主要的并发症，主要是由铜绿假单胞菌，肺炎克雷伯杆菌等引起[1]。临床上主要用抗生素治疗，包括喹诺酮类，大环内酯，氨基苷类等，但是由于抗生素的多样性以及各种副作用，为选择安全有效的药物治疗该病增加了难度[2]。因此，本研究探讨阿奇霉素对急性细菌性下呼吸道感染的治疗作用，现报道如下。
1资料与方法
1.1一般资料 选取2016年6月～2018年6月天津市宝坻区人民医院收治的急性细菌性下呼吸道感染患者96例，均符合该病诊断标准。按照随机数字表法分为对照组和实验组，各48例。对照组男20例，女28例;年龄18～72岁，平均年龄(48.12±0.47)岁;支气管患者16例，慢性阻塞性肺炎19例，感冒呼吸道感染13例。实验组男25例，女23例;年龄21～70岁，平均年龄(46.25±0.56)岁;支气管患者13例，慢性阻塞性肺炎23例，感冒呼吸道感染12例，两组年龄、性别、病情比较，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(冯瑞丰)
关键词：阿奇霉素;急性细菌性下呼吸道感染;左氧氟沙星
中图分类号：R56 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.11.045
, http://www.100md.com
文章编号：1006-1959(2019)11-0152-02
Abstract：Objective To analyze the efficacy and safety of azithromycin in patients with acute bacterial lower respiratory tract infection in our hospital.Methods The clinical data of 96 patients with acute bacterial lower respiratory tract infection admitted to our hospital from June 2016 to June 2018 were retrospectively analyzed. They were randomly divided into two groups， including 48 patients in the experimental group and treated with azithromycin，48 patients in the control group were treated with levofloxacin， and the clinical efficacy， duration of clinical symptoms， and adverse reactions were compared between the two groups.Results The total effective rate of the experimental group (95.83%) was higher than that of the control group (70.83%)，the difference was statistically significant (P<0.05). The duration of pulmonary snoring， fever and cough in the experimental group was shorter than that of the control group，the difference was statistically significant(P<0.05);the incidence of adverse reactions in the experimental group was lower than that in the control group(P<0.05).Conclusion Azithromycin is effective in the treatment of acute bacterial lower respiratory tract infections with few adverse reactions. It is one of the safe antibiotics for the treatment of acute bacterial lower respiratory tract infections.
, 百拇医药
Key words：Azithromycin;Acute bacterial lower respiratory tract infection;Levofloxacin
急性細菌性下呼吸道感染(acute bacterial lower respiratory tract infection)是临床呼吸道感染常见病，不仅多发于儿童，而且也是慢性阻塞性肺炎(COPD)主要的并发症，主要是由铜绿假单胞菌，肺炎克雷伯杆菌等引起[1]。临床上主要用抗生素治疗，包括喹诺酮类，大环内酯，氨基苷类等，但是由于抗生素的多样性以及各种副作用，为选择安全有效的药物治疗该病增加了难度[2]。因此，本研究探讨阿奇霉素对急性细菌性下呼吸道感染的治疗作用，现报道如下。
1资料与方法
1.1一般资料 选取2016年6月～2018年6月天津市宝坻区人民医院收治的急性细菌性下呼吸道感染患者96例，均符合该病诊断标准。按照随机数字表法分为对照组和实验组，各48例。对照组男20例，女28例;年龄18～72岁，平均年龄(48.12±0.47)岁;支气管患者16例，慢性阻塞性肺炎19例，感冒呼吸道感染13例。实验组男25例，女23例;年龄21～70岁，平均年龄(46.25±0.56)岁;支气管患者13例，慢性阻塞性肺炎23例，感冒呼吸道感染12例，两组年龄、性别、病情比较，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(冯瑞丰)