尿结石患者体重指数对血尿生化及结石成分的影响(1)
摘要：目的 分析尿路結石患者体重指数(BMI)对24h尿液、血液生化指标及结石成分的影响。方法 对2017年1月～2018年7月我院收治的尿路结石患者150例进行血尿生化分析，按照BMI分为体重正常组45例、超重组65例，肥胖组40例，检测24h尿钙、磷、尿酸、血钙、血磷、血尿酸及尿pH等指标，同时收集患者结石标本进行红外光谱结石成分分析。比较组间各指标及结石成分的差异性;根据结石成分不同分为四组(草酸钙组、磷酸钙组、尿酸组和磷酸镁铵组)，比较组间各指标的差异性。结果 超重组和肥胖组尿液pH均低于正常组(P<0.05);体重正常组患者24h尿钙、尿磷、尿酸和血磷、尿酸明显低于超重或肥胖组(P<0.05)。磷酸镁铵组患者尿液pH高于其它组(P<0.05)。尿酸组和磷酸钙组24h尿磷高于草酸钙组和磷酸镁铵组(P<0.05)。尿酸组24h尿酸高于其它组，磷酸镁铵组24h尿酸低于其它组(P<0.05)。尿酸组血尿酸高于其它组，磷酸镁铵组血尿酸低于磷酸钙组和尿酸组(P<0.05)。磷酸镁铵组BMI低于其它组(P<0.05)。肥胖组、超重组草酸钙、尿酸结石比例均高于正常组(P<0.05)，而磷酸镁铵比例则低于正常组(P<0.05)。BMI与尿液pH的相关性分析表明两者高度相关(r=-0.725，P<0.05)。结论 肥胖及超重对血尿生化、血生化、尿pH及结石成分比例有一定影响，且存在性别差异，建议肥胖或超重的尿结石患者行血尿生化、结石成分等评估，注意饮食控制、减重等措施。
关键词：尿路结石;结石成分;血尿生化;BMI
Abstract：Objective To analyze the effect of body mass index (BMI) on urinary calculi in 24h urine， blood biochemical parameters and stone composition.Methods According to the BMI， 150 patients with urinary calculi admitted to our hospital from January 2017 to July 2018 were divided into 45 normal weight group， 65 super-reformed group， 40 obese group， 24 h urinary calcium. Phosphorus， uric acid， blood calcium， blood phosphorus， blood uric acid and urine pH indicators， while collecting patient stone specimens for infrared spectral analysis of stone components. The differences between the indicators and the stone components were compared between the groups; the stones were divided into four groups (calcium oxalate group， calcium phosphate group， uric acid group and magnesium ammonium phosphate group)， and the differences among the indicators were compared.Results The urine pH of the super-recombinant and obese group were lower than the normal group， the difference was statistically significant (P<0.05). The 24 h urinary calcium， urinary phosphorus， uric acid， blood phosphorus and uric acid were significantly lower in the normal weight group than in the overweight or obese group(P<0.05). The urine pH of the patients in the ammonium magnesium phosphate group was higher than that in the other groups(P<0.05). The urinary phosphorus in the uric acid group and the calcium phosphate group 24 h was higher than that in the calcium oxalate group and the ammonium magnesium phosphate group(P<0.05). The uric acid group was higher than the other groups in 24 h， and the uric acid in the ammonium magnesium phosphate group 24 h was lower than the other groups(P<0.05). The uric acid group had higher blood uric acid than the other groups. The calcium urate group was lower than the calcium phosphate group and the uric acid group(P<0.05). The BMI of the ammonium magnesium phosphate group was lower than that of the other groups(P<0.05). The proportion of obese group， super recombinant calcium oxalate and uric acid stone was higher than normal group (P<0.05)， while the proportion of magnesium ammonium phosphate was lower than that of the normal group(P<0.05). Correlation analysis between BMI and urine pH showed that the two were highly correlated (r=-0.725， P<0.05).Conclusion Obesity and overweight have certain effects on hematuria biochemistry， blood biochemistry， urine pH and stone composition ratio， and there are gender differences. It is recommended that patients with obesity or overweight urinary stones should be evaluated for hematuria biochemistry and stone composition， pay attention to measures such as diet control， weight loss and other measures., http://www.100md.com(陈友干 向从明 卫冰冰)
关键词：尿路结石;结石成分;血尿生化;BMI
Abstract：Objective To analyze the effect of body mass index (BMI) on urinary calculi in 24h urine， blood biochemical parameters and stone composition.Methods According to the BMI， 150 patients with urinary calculi admitted to our hospital from January 2017 to July 2018 were divided into 45 normal weight group， 65 super-reformed group， 40 obese group， 24 h urinary calcium. Phosphorus， uric acid， blood calcium， blood phosphorus， blood uric acid and urine pH indicators， while collecting patient stone specimens for infrared spectral analysis of stone components. The differences between the indicators and the stone components were compared between the groups; the stones were divided into four groups (calcium oxalate group， calcium phosphate group， uric acid group and magnesium ammonium phosphate group)， and the differences among the indicators were compared.Results The urine pH of the super-recombinant and obese group were lower than the normal group， the difference was statistically significant (P<0.05). The 24 h urinary calcium， urinary phosphorus， uric acid， blood phosphorus and uric acid were significantly lower in the normal weight group than in the overweight or obese group(P<0.05). The urine pH of the patients in the ammonium magnesium phosphate group was higher than that in the other groups(P<0.05). The urinary phosphorus in the uric acid group and the calcium phosphate group 24 h was higher than that in the calcium oxalate group and the ammonium magnesium phosphate group(P<0.05). The uric acid group was higher than the other groups in 24 h， and the uric acid in the ammonium magnesium phosphate group 24 h was lower than the other groups(P<0.05). The uric acid group had higher blood uric acid than the other groups. The calcium urate group was lower than the calcium phosphate group and the uric acid group(P<0.05). The BMI of the ammonium magnesium phosphate group was lower than that of the other groups(P<0.05). The proportion of obese group， super recombinant calcium oxalate and uric acid stone was higher than normal group (P<0.05)， while the proportion of magnesium ammonium phosphate was lower than that of the normal group(P<0.05). Correlation analysis between BMI and urine pH showed that the two were highly correlated (r=-0.725， P<0.05).Conclusion Obesity and overweight have certain effects on hematuria biochemistry， blood biochemistry， urine pH and stone composition ratio， and there are gender differences. It is recommended that patients with obesity or overweight urinary stones should be evaluated for hematuria biochemistry and stone composition， pay attention to measures such as diet control， weight loss and other measures., http://www.100md.com(陈友干 向从明 卫冰冰)