血清ADA水平和T-spot.TB联合检测在肺结核诊断中的应用(1)
摘要：目的 研究肺結核诊断中的血清腺苷脱氨酶(ADA)水平和结核感染T细胞斑点试验(T-spot.TB)联合检测的价值。方法 选择2018年2月～2019年2月在我院拟诊为肺结核患者64例临床资料，分为肺结核组和非肺结核组，各32例。另选取同期健康体检者30例设为对照组，比较三组血清ADA水平、T-spot.TB斑点数，二者分别检测的阳性率、单独检测及联合检测肺结核的特异性、灵敏性、阳性预测值、阴性预测值。结果 肺结核组血清ADA水平高于非肺结核组和对照组(P<0.05);肺结核组血清ADA检测阳性率、T-spot.TB检测阳性率均高于对照组、非肺结核组(P<0.05);血清ADA水平和T-spot.TB平行检测诊断肺结核灵敏度和阴性预测值高于血清ADA、T-spot.TB单独检测，特异性和阳性预测值低于血清ADA、T-spot.TB单独检测(P<0.05)。联合检测特异性、阳性预测值高于血清ADA、T-spot.TB单独检测，灵敏度、阴性预测值低于血清ADA、T-spot.TB单独检测(P<0.05)。结论 血清ADA水平和T-spot.TB联合检测在肺结核诊断中具有重要作用，平行联合检测灵敏度高，联合检测特异性高。
关键词：血清ADA;T-spot.TB;联合检测;肺结核
中图分类号：R521;R446.11 文献标识码：A DOI：10.3969/j.issn.1006-1959.2020.05.058
文章编号：1006-1959(2020)05-0171-02
Abstract：Objective To study the value of combined detection of serum adenosine deaminase (ADA) levels and tuberculosis T-cell spot test (T-spot.TB) in the diagnosis of tuberculosis. Methods From February 2018 to February 2019， 64 clinical data of tuberculosis patients who were planned to be diagnosed in our hospital were selected. They were divided into tuberculosis group and non-tuberculosis group， with 32 cases in each group. Another 30 healthy subjects were selected as the control group; compared the levels of serum ADA and the numbers of T-spot.TB spots in the three groups， the positive rate， specificity， sensitivity， positive predictive value and negative predictive value of tuberculosis were tested separately， separately and in combination. Results The serum ADA levels in the tuberculosis group were higher than those in the non-tuberculosis group and the control group (P<0.05). The positive rates of ADA and T-spot.TB in the tuberculosis group were higher than those in the control group and non-tuberculosis group (P<0.05). The sensitivity and negative predictive value of serum ADA level and T-spot.TB combined detection in the diagnosis of tuberculosis are higher than those of serum ADA and T-spot.TB alone， and the specificity and positive predictive value are lower than those of serum ADA and T-spot.TB alone (P<0.05). The specificity and positive predictive value of combined detection were higher than those of serum ADA and T-spot.TB alone， and the sensitivity and negative predictive value were lower than those of serum ADA and T-spot.TB alone (P<0.05). Conclusion The combined detection of serum ADA level and T-spot.TB has an important role in the diagnosis of pulmonary tuberculosis. The parallel combined detection has high sensitivity and high specificity of combined detection., 百拇医药(丁媛)
关键词：血清ADA;T-spot.TB;联合检测;肺结核
中图分类号：R521;R446.11 文献标识码：A DOI：10.3969/j.issn.1006-1959.2020.05.058
文章编号：1006-1959(2020)05-0171-02
Abstract：Objective To study the value of combined detection of serum adenosine deaminase (ADA) levels and tuberculosis T-cell spot test (T-spot.TB) in the diagnosis of tuberculosis. Methods From February 2018 to February 2019， 64 clinical data of tuberculosis patients who were planned to be diagnosed in our hospital were selected. They were divided into tuberculosis group and non-tuberculosis group， with 32 cases in each group. Another 30 healthy subjects were selected as the control group; compared the levels of serum ADA and the numbers of T-spot.TB spots in the three groups， the positive rate， specificity， sensitivity， positive predictive value and negative predictive value of tuberculosis were tested separately， separately and in combination. Results The serum ADA levels in the tuberculosis group were higher than those in the non-tuberculosis group and the control group (P<0.05). The positive rates of ADA and T-spot.TB in the tuberculosis group were higher than those in the control group and non-tuberculosis group (P<0.05). The sensitivity and negative predictive value of serum ADA level and T-spot.TB combined detection in the diagnosis of tuberculosis are higher than those of serum ADA and T-spot.TB alone， and the specificity and positive predictive value are lower than those of serum ADA and T-spot.TB alone (P<0.05). The specificity and positive predictive value of combined detection were higher than those of serum ADA and T-spot.TB alone， and the sensitivity and negative predictive value were lower than those of serum ADA and T-spot.TB alone (P<0.05). Conclusion The combined detection of serum ADA level and T-spot.TB has an important role in the diagnosis of pulmonary tuberculosis. The parallel combined detection has high sensitivity and high specificity of combined detection., 百拇医药(丁媛)
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