摘要：免疫检查点抑制剂(ICIs)在肿瘤治疗方面取得了突破性进展。接受ICIs治疗的患者可能会因免疫系统活动上调而出现免疫相关不良事件(irAEs)。随着ICIs使用增加，irAEs的报道越来越频繁，并成为许多患者的重要挑战。神经系统irAEs包括脑炎、脊髓炎、脑膜炎、周围神经病、重症肌无力和肌炎等，由一组独特的神经炎症疾病组成。这些疾病罕见但严重，死亡率很高。神经系统irAEs患者通常对免疫调节疗法有反应。因此，早期识别和治疗是改善其预后的重要途径。

    关键词：免疫检查点抑制剂;免疫相关不良事件;神经毒性;糖皮质激素

    中图分类号：R730.5" " " " " " " " " " " " " " " " "文献标识码：A" " " " " " " " " " " " " " " " "DOI：10.3969/j.issn.1006-1959.2023.08.039

    文章编号：1006-1959(2023)08-0175-05

    Current Status and Research Progress in the Diagnosis and Management of

    Immune Checkpoint Inhibitor-related Neurotoxicity

    CHEN Hua-chun1，WU Xiao-yu1，CHEN Gui-yuan2，LU Zhou-xiao1，NI Xiao-wei1，DING Ming-xing2

    (1.Department of Respiratory and Critical Care Medicine，Jinhua Guangfu Cancer Hospital，Jinhua 321000，Zhejiang，China;

    2.School of Medicine，Jinhua Polytechnic，Jinhua 321007，Zhejiang，China)

    Abstract：Immune checkpoint inhibitors (ICIs) have made a breakthrough in cancer therapy. Patients treated with ICIs may develop immune-related adverse events (irAEs) due to the upregulated activity of the immune system. With the increasing use of ICIs ......