摘要：脓毒症是一种高死亡率的医疗紧急情况，快速启动抗菌治疗对脓毒症至关重要，由于缺乏准确的诊断方案及强有力的证据支撑安全地停止抗生素使用，抗菌药物持续时间通常超过疗程，不合理使用抗生素可导致药物不良事件、多重耐药菌产生等危害。因此，抗生素管理在脓毒症中非常重要。生物标志物对于优化抗生素管理的潜力已被广泛证实，本文主要针对常见生物标志物指导抗生素使用的国内外研究进行综述。

    关键词：脓毒症；抗生素；降钙素原；C反应蛋白；白细胞介素-6

    中图分类号：R459.7 " " " " " " " " " " " " " " " " "文献标识码：A " " " " " " " " " " " " " " " "DOI：10.3969/j.issn.1006-1959.2023.13.041

    文章编号：1006-1959(2023)13-0182-06

    Research Progress of Biomarkers in Guiding the Use of Antibiotics in Patients with Sepsis

    CHEN Xiang-yu1，2，PAN Xiao-yan1，2，LI Jing3，DAI Xiao-yu1

    (1.Department of Nephrology，Mianyang Central Hospital，Mianyang 621000，Sichuan，China;

    2.School of Clinical Medicine，Chengdu Medical College，Chengdu 610500，Sichuan，China;

    3.Department of Nephrology，Sichuan Mianyang 404 Hospital，Mianyang 621000，Sichuan，China)

    Abstract：Sepsis is a medical emergency with high mortality and rapid initiation of antimicrobial therapy is critical for sepsis. Due to the lack of an accurate diagnosis plan and strong evidence to support the safe discontinuation of antibiotics， the duration of antibiotics usually exceeds the course of treatment ......