摘要：双氢青蒿素(DHA)是青蒿素的衍生物，具有良好的抗疟疾作用，同时还具有良好的抗肿瘤作用。胃癌、肝癌、食管癌、直结肠癌等消化道肿瘤在全部肿瘤中所占的比例非常大，每年导致了数量巨大的死亡人数。研究表明DHA对消化系统肿瘤有良好的抑制作用，在临床上DHA已经被用来治疗各种消化系统肿瘤。本文就DHA对食管癌、胃癌、直结肠癌、肝癌、胰腺癌 胆囊癌等消化系统肿瘤的作用及其分子机制的研究做一综述，为DHA治疗消化道肿瘤的进一步研究奠定基础。

    关键词：双氢青蒿素；消化道肿瘤；抗癌作用；分子机制

    中图分类号：R735.2" " " " " " " " " " " " " " " " " 文献标识码：A" " " " " " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2023.14.038

    文章编号：1006-1959(2023)14-0173-06

    Research Progress on the Function and Mechanism of Dihydroartemisinin

    in Digestive Tract Tumors

    ZHANG Ya-qi1，PAN Ming-sheng2，TIAN Yan-jun2，ZHANG Guo-rong3

    (1.Department of Oncology，Tianshui Cooperation Traditional Chinese and Western Medicine Hospital，Tianshui 741020，Gansu，China;

    2.Department of Gastroenterology，Tianshui Cooperation Traditional Chinese and Western Medicine Hospital，

    Tianshui 741020，Gansu，China;

    3.Department of Pharmacy，the First Hospital of Lanzhou University，Lanzhou 730000，Gansu，China)

    Abstract：Dihydroartemisinin (DHA) is a derivative of artemisinin， which has good anti-malarial and anti-tumor effects. Digestive tract tumors such as gastric cancer ......