摘要：造血干细胞移植(HSCT)患者在接受放化疗治疗期间会出现消化和免疫功能紊乱，引起营养成分摄入减少、消化道功能降低以及肠道菌群失衡。营养支持治疗能够维持移植前后的营养状态，预防或减少移植后并发症。给予营养支持治疗能够改善HSCT患者的营养状况，通过调节肠道菌群来改善移植后并发症，影响体内细胞代谢物水平，降低移植后并发症发生风险。对HSCT患者行营养支持治疗过程中应关注可能伴发的导管相关性并发症、代谢并发症等。本文主要分析HSCT患者出现营养不良的原因，对近年来营养支持治疗对HSCT患者移植前后的营养状态和肠道菌群的影响进行综述。

    关键词：造血干细胞移植；营养支持治疗；肠道菌群

    中图分类号：R730.5" " " " " " " " " " " " " " " " "文献标识码：A" " " " " " " " " " " " " " " " "DOI：10.3969/j.issn.1006-1959.2023.14.041

    文章编号：1006-1959(2023)14-0188-05

    Research Progress on the Effect of Nutritional Support Therapy on Nutritional Status of Patients

    with Hematopoietic Stem Cell Transplantation

    LIU Xiao-xia，CHEN Xiao-yu

    (Department of Pharmacy，the People's Hospital of Guangxi Zhuang Autonomous Region，Nanning 530021，Guangxi，China)

    Abstract：During radiotherapy and chemotherapy treatment， hematopoietic stem cell transplantation (HSCT) patients can result in digestive and immune dysfunction， resulting in reduced nutrient intake， reduced digestive tract function and intestinal flora imbalance. Nutritional support therapy can maintain nutritional status before and after transplantation and prevent or reduce post-transplantation complications. Nutritional support therapy can improve the nutritional status of HSCT patients ......