摘要：胃癌在全球最普遍被诊断的癌症中排名第4，而且在所有癌症中死亡率排名第2，被视为国际上最重要的健康危机之一。遗传、生活环境、饮食习惯等诸多因素都会导致胃癌的发生。ω-3多不饱和脂肪酸(ω-3PUFAs)具有多种生物活性功能，并且在癌症的防治方面发挥着重要作用。目前，ω-3PUFAs在防治胃癌中作用及应用是这方面研究的热点。本文综述了ω-3PUFAs抑制胃癌细胞的作用及其机理、ω-3PUFAs预防及治疗胃癌等方面的研究，以期为ω-3PUFAs治疗胃癌的进一步研究提供思路。

    关键词：ω-3多不饱和脂肪酸；胃癌；抑制活性；化疗；DHA；EPA

    中图分类号：R735.2" " " " " " " " " " " " " " " " " 文献标识码：A" " " " " " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2023.16.035

    文章编号：1006-1959(2023)16-0169-05

    Study on the Inhibitory Effect and Prevention of ω-3 Polyunsaturated Fatty Acids

    on Gastric Cancer Cells

    ZHANG Ya-qi1，CAO Yin-ke2，TIAN Yan-jun2，ZHANG Guo-rong3

    (1.Department of Oncology，Tianshui Combine Traditional Chinese and Western Medicine Hospital，Tianshui 741020，Gansu，China;

    2.Department of Gastroenterology，Tianshui Combine Traditional Chinese and Western Medicine Hospital，

    Tianshui 741020，Gansu，China;

    3.Department of Pharmacy，the First Hospital of Lanzhou University，Lanzhou 730000，Gansu，China)

    Abstract：Gastric cancer is the fourth most commonly diagnosed cancer in the world and the second highest mortality rate among all cancers ......