摘要：卵巢癌(OC)是女性生殖系统最常见的恶性肿瘤之一，由于化疗耐药的发生，致死率高，且易复发，严重威胁女性健康。核因子E2相关因子(NRF2)是一种重要的转录因子，在防止活性氧(ROS)等介导的氧化应激损伤方面发挥着关键作用。然而，癌细胞中NRF2激活是导致化疗耐药性发生发展的原因，使药物介导的氧化应激失活，而氧化应激通常导致癌细胞死亡。本文主要综述了NRF2在卵巢癌中的作用关系，总结NRF2在卵巢癌常见化疗药物耐药中的作用，旨在阐明NRF2、氧化应激与卵巢癌之间关系的研究，经典的NRF2抑制剂及其化合物在卵巢癌的防治中可能起到的重要作用。

    关键词：核因子E2相关因子；卵巢癌；活性氧；氧化应激

    中图分类号：R737.31" " " " " " " " " " " " " " " " 文献标识码：A" " " " " " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2023.16.037

    文章编号：1006-1959(2023)16-0179-05

    Research Progress on the Role of NRF2 Signaling Pathway in Ovarian Cancer

    CHEN Yu-mei1，CHEN Cai-yun1，MA Zhen1，FU Ai-zhen2

    (1.The First Clinical Medical College of Guangdong Medical University，Zhanjiang 524000，Guangdong，China;

    2.Department of Obstetrics and Gynecology，Affiliated Hospital of Guangdong Medical University，

    Zhanjiang 524000，Guangdong，China)

    Abstract：Ovarian cancer (OC) is one of the most common malignant tumors in the female reproductive system tumors. Due to the occurrence of chemotherapy resistance， the mortality rate is high， and it is easy to relapse， which seriously threatens women's health. Nuclear factor E2 related factor (NRF2) is an important transcription factor ......