摘要：目的" 探讨PI3K/Akt/mTOR信号转导通路蛋白及RACK1在宫颈鳞状细胞癌中的表达及意义，以及与临床病理参数间的关系。方法" 选取2014年1月-2020年12月淄博市市立医院59例宫颈鳞癌组织及45例非肿瘤宫颈组织，用链霉亲和素-过氧化物酶免疫组化染色检测RACK1和PI3K、Akt、mTOR蛋白的表达。结果" RACK1在宫颈鳞癌组织中的阳性表达率低于非肿瘤宫颈组织(P<0.05)；PI3K、Akt、mTOR在宫颈鳞癌组织中的阳性表达率高于非肿瘤宫颈组织(P<0.05)；PI3K和mTOR在宫颈鳞癌中的表达与淋巴结转移及TNM分期相关(P<0.05)。结论" 宫颈鳞癌组织中RACK1表达下调，PI3K、Akt、mTOR表达上调。PI3K/Akt/mTOR信号转导通路可能参加了宫颈鳞癌的发生发展过程。

    关键词：RACK1；PI3K；Akt；mTOR；宫颈鳞癌

    中图分类号：R737.33" " " " " " " " " " " " " " " "文献标识码：A" " " " " " " " " " " " " " " " "DOI：10.3969/j.issn.1006-1959.2023.17.020

    文章编号：1006-1959(2023)17-0107-04

    Expression of Activated Protein Kinase C Receptor 1 in Cervical Squamous Cell Carcinoma

    and its Relationship with PI3K/Akt/mTOR Signal Transduction Pathway

    WANG Rui-cai，ZHU Jian-you

    (Department of Pathology，Zibo Municipal Hospital，Affiliated to Binzhou Medical College ......