作者简介：雷希君(1996.11-)，女，湖北武汉人，硕士研究生，住院医师，主要从事胸腔灌注治疗临床研究

    通讯作者：罗利琼(1977.10-)，女，湖北武汉人，博士，主任医师，硕士生导师，主要从事分子靶向治疗和免疫治疗

    摘要：恶性胸腔积液(MPE)是恶性肿瘤常见的相关并发症，一旦出现就提示病情进入了恶化阶段，临床治疗存在非常大的困难，因常可伴随引起胸痛胸闷、喘气等多种症状，耐受力明显下降，严重影响患者的生存质量及预后。目前，胸腔内直接局部灌注抗肿瘤药物的治疗方法应用较为广泛。本文从胸膜硬化剂、热疗、化疗药物、生物免疫抑制剂、中药制剂、抗血管生成剂及载药囊泡等方面入手，分析各类药物的特点及临床应用，以期为未来MPE的研究及治疗提供一定的参考依据。

    关键词：灌注治疗；恶性胸腔积液；囊泡；热疗；恩度

    中图分类号：R734.3" " " " " " " " " " " " " " " " 文献标识码：A" " " " " " " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2024.03.039

    文章编号：1006-1959(2024)03-0184-05

    Research Status of Intracavitary Perfusion in the Treatment of Malignant Pleural Effusion

    LEI Xi-jun，LUO Li-qiong

    (Department of Oncology，Tianyou Hospital，Wuhan University of Science and Technology，Wuhan 430064，Hubei，China)

    Abstract：Malignant pleural effusion(MPE) is a common complication of malignant tumors. Once it occurs， it indicates that the condition has entered a stage of deterioration. There are great difficulties in clinical treatment. Because it can often be accompanied by chest pain， chest tightness， wheezing and other symptoms ......