苟园 杨彬

    摘要：动脉粥样硬化(AS)是一种常见的慢性炎症性疾病，也是心血管疾病最常见的原因之一，已然是全球心血管疾病死亡主要因素之一。目前已知多种细胞与分子参与了AS的形成与发展，但机制尚不明确。NF-κB作为一种炎性反应调控因子，其调节的生物过程十分广泛。近年来有研究表明，NF-κB信号通路在AS发生、发展的数个阶段(包括氧化应激反应、内皮细胞损伤、平滑肌增生迁移等众多病理生理过程)中起关键作用。基于此，本文就NF-κB信号通路及其抑制剂在AS发病机制中的调控作用与相关机制作一综述。

    关键词：NF-κB信号通路；NF-κB信号抑制剂；动脉粥样硬化；血管细胞；炎症细胞

    中图分类号：R543.5? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 文献标识码：A? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? DOI：10.3969/j.issn.1006-1959.2024.04.035

    文章编号：1006-1959(2024)04-0178-05

    Research Progress on the Correlation Between NF-κB Pathway and Atherosclerosis

    GOU Yuan1，YANG Bin2

    (1.Clinical Medical College of Jining Medical University，Jining 272000，Shandong，China;

    2.Department of Vascular Surgery，Jining First People's Hospital，Jining 272000，Shandong，China)

    Abstract：Atherosclerosis (AS) is a common chronic inflammatory vascular disease that is one of the most common causes of cardiovascular disease and has been a major contributor to cardiovascular mortality worldwide. A variety of cells and molecules are known to be involved in the formation and development of AS， but the mechanisms are not yet clear. NF-κB ......