摘要：牙本质是构成牙体的重要硬组织，其形成受到严格的基因遗传调控。掌握这个庞大的基因网络调控系统有利于阐明牙本质发育、再生和修复过程的分子机制，进一步开发牙本质相关疾病的新型研究思路和治疗方式，帮助解决人类的牙齿疾病。针对调控牙本质形成的生长因子、转录因子等信号分子，本综述对于调控牙本质形成的信号通路和基因进行系统总结，以期为牙本质发育研究和疾病治疗提供理论和实验参考。

    关键词：信号通路；成牙本质细胞；牙本质

    中图分类号：R781.3" " " " " " " " " " " " " " " " " 文献标识码：A" " " " " " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2024.07.035

    文章编号：1006-1959(2024)07-168-05

    Research Progress of Signaling Pathways on Regulating Dentinogenesis

    WU Yin-lin1，ZENG Guo-jin2，WANG Qing-long2，SUN Mei-qun1，LIU Yu-dong1

    (Department of Basic Medicine1，Department of Stomatology2，Bengbu Medical College，Bengbu 233000，Anhui，China)

    Abstract：Dentin is an important hard tissue of the tooth. Dentinogenesis is strictly under genetic regulation. Mastering this huge network of regulation system is beneficial to elucidate the molecular mechanism of dentin development， regeneration and repair， and further develop novel research ideas and treatment methods for dentin related diseases， which will help to solve some dental diseases. Aiming at the growth factors， transcription factors and other signaling molecules that regulate dentin formation ......