摘要：腰椎退变性疾病常引起慢性腰痛，腰椎减压及融合手术是治疗腰椎退变性疾病的主要有效方法，取得了显著的临床效果，但长期随访发现腰椎融合术后邻近节段病变发生率并不低，是导致二次手术的主要因素。腰椎融合术后邻近节段退变发生机制涉及生物力学、生理病理学、分子生物学等诸多学科和因素，是一个复杂的生理病理发展过程。本文就腰椎融合术后邻近节段病变的发生因素及机制进行综述，以期为临床外科制定手术方案提供理论参考，并为干预邻近节段病变提供理论依据。

    关键词：腰椎融合；邻近节段退变；生物力学

    中图分类号：R687.3" " " " " " " " " " " " " " " " "文献标识码：A" " " " " " " " " " " " " " " " "DOI：10.3969/j.issn.1006-1959.2024.10.036

    文章编号：1006-1959(2024)10-0165-05

    Research Progress on Factors and Mechanism of Adjacent Segment Degeneration After Lumbar Fusion

    OU Yu-fu1，2，XIAO Zeng-ming2

    (1.Department of Orthopaedics，Guangxi Hospital，the First Affiliated Hospital of Sun Yat-sen University，Nanning 530022，Guangxi，China;2.Graduate School of Guangxi Medical University，Nanning 530021，Guangxi，China)

    Abstract：Degenerative diseases of the lumbar spine often cause chronic low back pain. Lumbar decompression and fusion surgery is the main and effective method for the treatment of degenerative diseases of the lumbar spine， and has achieved remarkable clinical results. However， long-term follow-up found that the incidence of adjacent segment lesions after lumbar fusion was not low ......