石磊 任婷婷 谭云 舒漪 陈玲

    摘要：胰十二指肠切除术是临床常见术式，但术后会出现一系列症候群，加之癌因性疲乏(CRF)影响，进而降低患者生活质量。随着对胰腺癌术后患者症状群的研究，发现系统的症状管理与治疗对提高患者的生活质量具有重要意义。不悦症状理论(TOUS)是症状相关的中域理论之一，通过介绍患者面对不舒适症状时可能出现的身心反应，构建个体症状整体情况，进一步为制定个性化整体治疗方案提供理论基础。但目前TOUS理论主要被应用于肺癌、心衰、乳腺癌、结肠癌等患者，胰腺癌相关研究较少。本文基于TOUS胰腺癌术后患者症状群与CRF、生活质量进行综述，以期为胰腺癌术后患者制定改善临床症状治疗方法提供新的方向。

    关键词：胰腺癌；不悦症状理论；癌因性疲乏；生活质量

    中图分类号：R735.9? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?文献标识码：A? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?DOI：10.3969/j.issn.1006-1959.2024.12.041

    文章编号：1006-1959(2024)12-0179-04

    Study on Symptom Clusters， CRF and Quality of Life of Postoperative Patients

    with Pancreatic Cancer Based on TOUS

    Abstract：Pancreaticoduodenectomy is a common clinical operation， but a series of symptoms will appear after operation， coupled with cancer-related fatigue (CRF)， which will reduce the quality of life of patients. With the study of symptom clusters in patients with pancreatic cancer after surgery， it has been found that systematic symptom management and treatment are of great significance to improve the quality of life of patients. The theory of unpleasant symptoms (TOUS) is one of the middle domain theories related to symptoms. By introducing the possible physical and mental reactions of patients in the face of uncomfortable symptoms ......