摘要：三阴性乳腺癌(TNBC)是最具侵袭性的乳腺癌亚型，恶性程度高。由于缺乏有效的诊断和治疗，缺乏特异性靶点和靶向治疗，多药耐药等因素，目前可用的治疗方法在TNBC治疗中效果明显较差。与三阴性乳腺癌相关的基因常见BRCA1/2、TLR3、CDKN2A、IFNG、ACSS2、IRS2、ZNF33A等。本文对TNBC诊断、预后预测、治疗、耐药等相关靶点及TNBC的基因递送系统进行综述，以期为临床治疗及药物研发提供思路。

    关键词：三阴性乳腺癌；诊断与预后；基因治疗；耐药

    中图分类号：R737.9" " " " " " " " " " " " " " " " "文献标识码：A" " " " " " " " " " " " " " " " "DOI：10.3969/j.issn.1006-1959.2024.17.042

    文章编号：1006-1959(2024)17-0188-05

    Research Status of Triple-negative Breast Cancer Related Targets

    WEI Xue-ni，YANG Zhong-hui，HUANG Ji，CHEN Guo-mei，CHEN Xiao

    (Department of Pharmacy，the First Taicang Hospital Affiliated to Suzhou University，Taicang 215400，Jiangsu，China)

    Abstract：Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with high malignancy. Due to the lack of effective diagnosis and treatment， lack of specific targets and targeted therapy， multidrug resistance and other factors， the current available treatment methods have a significantly poor effect in the treatment of TNBC. BRCA1/2， TLR3， CDKN2A， IFNG， ACSS2， IRS2， ZNF33A， etc. are common genes associated with triple-negative breast cancer. This article reviews the related targets of TNBC diagnosis ......