摘要：目的" 探讨西替利嗪与布地奈德联用对小儿哮喘急性发作期肺功能的影响。方法" 选择2020年3月-2022年3月在信丰县人民医院接受治疗的78例哮喘急性发作期患儿为研究对象，采用随机数字表法将其分成对照组和观察组，每组39例。对照组采用布地奈德吸入治疗，观察组采用布地奈德联合西替利嗪治疗。比较两组治疗前后肺功能[第1秒用力呼气容量(FEV1)、用力肺活量(FVC)和呼气高峰流量(PEFR)]、临床疗效、炎性指标[白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、C反应蛋白(CRP)]及不良反应发生率。结果" 观察组FEV1、 FVC、 PEFR均优于对照组(P<0.05)；观察组总有效率高于对照组(P<0.05)；观察组IL-6、CRP水平低于对照组，IL-10水平高于对照组(P<0.05)；观察组不良反应发生率低于对照组(P<0.05)。结论" 西替利嗪与布地奈德联用治疗小儿哮喘急性发作期的疗效确切，可提高患儿的肺功能，同时具有良好的抗炎作用及安全性，值得临床应用。

    关键词：小儿哮喘急性发作期；西替利嗪；布地奈德吸入；肺功能

    中图分类号：R725.6" " " " " " " " " " " " " " " " " "文献标识码：A" " " " " " " " " " " " " " " "DOI：10.3969/j.issn.1006-1959.2024.18.014

    文章编号：1006-1959(2024)18-0079-04

    Abstract：Objective" To investigate the effect of cetirizine combined with budesonide on pulmonary function in children with acute attack of asthma.Methods" A total of 78 children with acute exacerbation of asthma who were treated in Xinfeng County People's Hospital from March 2020 to March 2022 were selected as the research objects. They were divided into control group and observation group by random number table method ......