摘要：目的" 探究尿毒清颗粒联合包醛氧淀粉治疗慢性肾衰竭(CRF)的临床疗效及对氧化应激指标的影响。方法" 以2021年4月-2023年5月吉水县人民医院收治的62例CRF患者为研究对象，经随机数字表法分为对照组(31例)和观察组(31例)，对照组给予包醛氧淀粉口服治疗，观察组在其基础上联合尿毒清颗粒治疗，比较两组临床疗效、中医症状积分(恶心呕吐、面浮肢肿、倦怠乏力)、肾功能指标[血肌酐(Cr)、尿素氮(BUN)、尿微量白蛋白(ALB)]、氧化应激指标[C反应蛋白(CRP)、超氧化物歧化酶(SOD)、丙二醛(MDA)]。结果" 观察组总有效率高于对照组(P<0.05)。两组治疗后恶心呕吐、面浮肢肿、倦怠乏力积分均低于治疗前，且观察组恶心呕吐、面浮肢肿、倦怠乏力积分低于对照组(P<0.05)；两组治疗后Cr、BUN、ALB低于治疗前，且观察组Cr、BUN、ALB低于对照组(P<0.05)；两组治疗后CRP、MDA低于治疗前，SOD高于治疗前，且观察组CRP、MDA低于对照组，SOD高于对照组(P<0.05)。结论" 尿毒清颗粒联合包醛氧淀粉治疗CRF疗效肯定，可有效缓解患者症状，改善其肾功能，减轻机体氧化应激状态。

    关键词：慢性肾衰竭；尿毒清颗粒；包醛氧淀粉；氧化应激；肾功能

    中图分类号：R692.5" " " " " " " " " " " " " " " " " 文献标识码：A" " " " " " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2024.18.020

    文章编号：1006-1959(2024)18-0104-04

    Abstract：Objective" To explore the clinical efficacy of Niaoduqing granules combined with coated aldehyde oxystarch in the treatment of chronic renal failure (CRF) and its effect on oxidative stress indexes.Methods" A total of 62 patients with CRF admitted to Jishui County People's Hospital from April 2021 to May 2023 were enrolled in the study. They were divided into control group (31 patients) and observation group (31 patients) by random number table method. The control group was given oral treatment of coated aldehyde oxystarch ......