摘要：中药雷公藤对类风湿性关节炎、糖尿病、肾病等多种疾病具有疗效，但其对肝脏、心脏、肾脏等多个器官系统存在毒副作用，导致雷公藤的使用产生安全性问题。随着技术的进步，多种减毒策略逐渐出现，研究者不仅运用炮制、中药配伍、改变给药剂型等方法对雷公藤进行减毒增效，还通过生物信息学技术结合多种现代生物学手段研究中药雷公藤有毒成分的作用机制，进而减除其有毒成分，为解决雷公藤存在的毒副作用，提高其利用率提供了新的途径。本综述对目前已有的提取中药雷公藤有毒成分的筛选方法进行归纳总结，同时探讨利用生物信息学的方法预测中药雷公藤毒性成分的靶点，为雷公藤的减毒研究奠定基础。

    关键词：雷公藤;毒副作用;减毒策略

    中图分类号：R285" " " " " " " " " " " " " " " " " " "文献标识码：A" " " " " " " " " " " " " " " "DOI：10.3969/j.issn.1006-1959.2024.19.041

    文章编号：1006-1959(2024)19-0189-04

    Toxicity and Side Effects of Main Components of Traditional Chinese Medicine Tripterygium

    Wilfordii and its Solution Strategy

    WANG YiRan1，2，WEN GuiLan1，2，YANG Ying1，2

    (1.College of Animal Science，Guizhou University，Guiyang 550025，Guizhou，China;

    2.Guizhou Engineering Research Center of Animal Biological Products，Guiyang 550016，Guizhou，China)

    Abstract： Traditional Chinese medicine Tripterygium wilfordii has curative effect on rheumatoid arthritis， diabetes mellitus， kidney disease and other diseases， but it has toxicity and side effects on liver， heart， kidney and other organ systems， resulting in safety problems in the use of Tripterygium wilfordii. With the progress of technology ......