摘要：目的 研究联合干扰素γ与沐舒坦雾化吸入治疗慢性支气管炎急性发作的临床疗效。方法 选取2021年1月-2023年3月我院诊治的61例慢性支气管炎急性发作患者为研究对象，采用随机数字表法分为对照组(n=31)和观察组(n=30)。对照组采用干扰素γ治疗，观察组在对照组基础上联合给予沐舒坦雾化吸入治疗，比较两组临床疗效、临床症状改善时间、肺功能指标[呼气峰流速(PEF)、肺活量(FVC)、第1秒最大呼气量(FEV1)]、不良反应发生率。结果 观察组治疗总有效率为96.67%，高于对照组的83.87%(P<0.05);观察组咳嗽、咳痰、喘息消失时间均短于对照组(P<0.05);两组治疗后PEF、FVC、FEV1均高于治疗前，且观察组高于对照组(P<0.05);观察组不良反应发生率与对照组比较，差异无统计学意义(P>0.05)。结论 联合干扰素γ与沐舒坦雾化吸入治疗急性发作慢性支气管炎的临床疗效确切，可促进临床症状消退，改善肺功能，且不良反应发生率低，是一种可行、有效的治疗方案。

    关键词：干扰素γ;沐舒坦;雾化吸入;慢性支气管炎;急性发作

    中图分类号：R562 文献标识码：A DOI：10.3969/j.issn.1006-1959.2024.20.025

    文章编号：1006-1959(2024)20-0123-04

    Clinical Effect of Combined Interferon γ and Mucosolvan Aerosol Inhalationin the Treatment of Acute Attack of Chronic Bronchitis

    ZENG Xiangbin，DENG Jiaqi，ZHANG Pengfei，ZENG Lili，WU Dan

    (Department of Respiratory Medicine，Jishui County People's Hospital，Jishui 331600，Jiangxi，China)

    Abstract：Objective To study the clinical efficacy of combined interferon γ and mucosolvan aerosol inhalation in the treatment of acute exacerbation of chronic bronchitis.Methods A total of 61 patients with acute exacerbation of chronic bronchitis diagnosed and treated in our hospital from January 2021 to March 2023 were selected as the research objects. They were divided into control group (n=31) and observation group (n=30) by random number table method. The control group was treated with interferon γ ......