摘要：宫颈癌严重威胁女性健康，寻找早期诊断敏感指标非常重要。环状RNAs(circRNAs)通过充当microRNA海绵与蛋白质相互作用参与恶性肿瘤的发生发展。circMTO1在许多恶性肿瘤中异常表达，在宫颈癌中，circMTO1通过miR-6893/S100A1通路可能以调节细胞周期、促进抗凋亡途径、促进血管形成的方式，以及通过miR-6893/自噬信号以促进DNA及染色体的损伤、诱发细胞氧化损伤的方式参与宫颈癌发生发展。本文对上述发生机制进行总结，以期为宫颈癌的诊断提供新思路。

    关键词：宫颈癌;circMTO1;miR-6893;S100A1;自噬

    中图分类号：R737.33 文献标识码：A DOI：10.3969/j.issn.1006-1959.2024.20.040

    文章编号：1006-1959(2024)20-0183-05

    Study on the Role of circMTO1 in the Development of Cervical Cancer

    WEN Ting1，LU Huixia1，2

    (1.Clinical Medical College，Dali University，Dali 671000，Yunnan，China;

    2.Department of Gynecology，the First Affiliated Hospital of Dali University，Dali 671000，Yunnan，China)

    Abstract：Cervical cancer is a serious threat to women's health. It is very important to find sensitive indicators for early diagnosis. circular RNAs (circRNAs) are involved in the occurrence and development of malignant tumors by acting as microRNA sponges to interact with proteins. circMTO1 is abnormally expressed in many malignant tumors. In cervical cancer， circMTO1 may participate in the development of cervical cancer by regulating cell cycle ......