摘要：激素抵抗型肾病综合征(SRNS)经足量激素治疗8～12周无效，文献调研显示肾病综合征发生激素抵抗的机制与激素的药代动力学受损和肾脏自身结构、功能受损相关。本文将从糖皮质激素受体、伴侣蛋白，及足细胞相关基因和蛋白的角度对SRNS发病机制的研究成果进行综述，以期对SRNS的临床研究及新药研发提供思路。

    关键词：激素抵抗型肾病综合征；发病机制；糖皮质激素受体；基因；蛋白

    中图分类号：R692" " " " " " " " " " " " " " " " " "文献标识码：A" " " " " " " " " " " " " " " " "DOI：10.3969/j.issn.1006-1959.2025.03.034

    文章编号：1006-1959(2025)03-0165-05

    Research Status of Pathogenesis of Steroid-resistant Nephrotic Syndrome

    DUAN Shuwen， DING Zhaoran， LIU Can， DAI Enlai

    (College of Integrated Traditional Chinese and Western Medicine， Gansu University

    of Traditional Chinese Medicine， Lanzhou 730000， Gansu， China)

    Abstract： Steroid-resistant nephrotic syndrome (SRNS) is ineffective after 8-12 weeks of sufficient hormone therapy. Literature research shows that the mechanism of hormone resistance in nephrotic syndrome is related to the impaired pharmacokinetics of hormones and the impaired structure and function of the kidney itself. This article will review the research results of the pathogenesis of SRNS from the perspectives of glucocorticoid receptors， chaperone proteins ......