摘要：肠道微生物菌群在维持人体肠道内环境中的重要性逐渐得以揭示，其代谢产物直接参与慢性肾脏病尿毒症毒素积累。慢性肾脏病是由进行性毒素堆积引起贫血、容量负荷过重、电解质紊乱、矿物质和骨骼疾病和代谢性酸中毒等临床症状，其与肠道微生物群之间的相互作用越来越受关注。大量研究表明慢性肾脏病与肠道微生物稳态失衡的病理改变是通过上调产生特定有害毒素的微生物群丰度与减少产生有益产物的微生物群而互为因果。本文就肠道微生物变化及其代谢产物与慢性肾脏病尿毒症毒素之间的潜在相互作用进行综述，旨在为延缓肾功能进展提供临床治疗依据。

    关键词：慢性肾脏病；肾功能不全；肠道微生物菌群；尿毒症毒素

    中图分类号：R259" " " " " " " " " " " " " " " " " 文献标识码：A" " " " " " " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2025.03.038

    文章编号：1006-1959(2025)03-0184-04

    Effect of Intestinal Microbial Homeostasis Disorder on Chronic Kidney Disease Toxins

    LI Yu， WANG Jing

    (Department of Nephrology， Luohu Hospital of Traditional Chinese Medicine，

    Shenzhen 518001， Guangdong， China)

    Abstract：The importance of gut microbiota in maintaining the internal environment of the human gut has gradually been revealed， and its metabolites are directly involved in the accumulation of uremic toxins in chronic kidney disease. Chronic kidney disease (CKD) is a clinical symptom caused by progressive toxin accumulation， such as anemia， volume overload， electrolyte imbalance， mineral and bone diseases ......