摘要： 非酒精性脂肪肝的全球流行率不断上升，与生活方式和饮食习惯的改变密切相关。尿酸是一种内源性代谢产物，近年来越来越多的研究表明高尿酸血症与非酒精性脂肪肝之间存在密切的相关性。基于此，本文首先对高尿酸血症与非酒精性脂肪肝相关性展开研究，其次阐述不同体型与性别的高尿酸血症患者发生非酒精性脂肪肝的差异，最后重点总结高尿酸血症导致非酒精性脂肪肝可能的病理分子机制，以期为临床治疗提供参考。

    关键词： 非酒精性脂肪肝；高尿酸血症；代谢性疾病；生物标志物

    中图分类号：R575.5" " " " " " " " " " " " " " " " " " " " 文献标识码：A" " " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2025.04.034

    文章编号：1006-1959(2025)04-0176-06

    Research Progress on the Correlation Between Hyperuricemia and Nonalcoholic Fatty Liver Disease

    DU Shenglan1， HE Qian2， ZENG Jun1， ZHAO Weimin1

    (1.Department of Endocrinology， First Clinical Medical College of China Three Gorges University/

    Yichang Central People′s Hospital， Yichang 443000， Hubei， China;

    2.Department of Metabolism and Endocrinology， the Second Xiangya Hospital of Central South University/Hunan Primary Laboratory of Metabolic Osteopathy/National Center for Clinical Medical Research of Metabolic Diseases， Changsha 410011， Hunan， China)

    Abstract： The global prevalence of nonalcoholic fatty liver disease is increasing， which is closely related to changes in lifestyle and eating habits. Uric acid is an endogenous metabolite. In recent years ......