肠道微生态在隐匿性肝性脑病中发病机制及治疗前景
摘要:隐匿性肝性脑病(CHE)是指通过神经心理学和(或)神经生理学发现异常,但患者可无症状或仅表现为轻度的认知障碍、失眠、睡眠倒错、计算力和注意力减弱等症状的一种肝性脑病,它不同于显性肝性脑病(OHE)出现的定向力障碍、扑翼样震颤等肝性脑病的典型症状,这种类型的肝性脑病不易被察觉。CHE易发展为OHE,降低了肝硬化患者的生存率,还影响患者精细操作能力,增加意外伤害风险,加重家庭和社会的负担。隐匿性肝性脑病发生的确切机制并未明确。近年来研究发现,肠道微生态的变化与肝性脑病的发生、发展及预后有密切的相关。本文旨在系统地对肠道微生态在隐匿性肝性脑病中的发生机制及治疗前景进行综述,深入探讨两者之间的关联,为临床防治CHE的手段提供理论依据。关键词:肝性脑病;隐匿性肝性脑病;肠道微生态;益生元;益生菌
中图分类号:R575.3" " " " " " " " " " " " " " " " "文献标识码:A" " " " " " " " " " " " " " " " "DOI:10.3969/j.issn.1006-1959.2025.04.036
文章编号:1006-1959(2025)04-0188-05
The Pathogenesis and Treatment Prospect of Intestinal Microecology
in Occult Hepatic Encephalopathy
WEI Yingying1, HE Wanrong2, LIANG Yunxiao2, LING Mingxia3
(1.Graduate School of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China;
2.Gastroenterology Department of Guangxi Zhuang Autonomous Region People′s Hospital, Nanning 530022, Guangxi, China;
3.Guilin Medical University, Guilin 541000, Guangxi, China)
Abstract: Covert hepatic encephalopathy (CHE) refers to a type of hepatic encephalopathy characterized by abnormalities discovered through neuropsychology and/or neurophysiology ......
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