摘要：目的" 探讨血脂血尿酸(UA)、血同型半胱氨酸(HCY)水平与帕金森病(PD)病情严重程度的相关性。方法" 选取2021年1月-2024年8月就诊于我院神经内科的92例PD患者，设为PD组；选取体检中心92名同期健康体检者，设为健康对照(HC)组，检测两组总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白(LDL-C)、HCY、UA水平，并计算出残余胆固醇(RC)，分析PD病情严重程度的影响因素，采用受试者工作特征曲线下面积评估血脂、HCY、UA对PD发病的预测价值。结果" PD组TC、TG、LDL-C、RC、UA水平均低于HC组，HCY水平高于HC组(P<0.05)。二元Logistic回归分析结果显示，TC、LDL-C、RC、HCY、UA水平与PD发病相关(P<0.05)。相关性分析显示，PD组RC与病情严重程度明显相关(P<0.05)，RC、TC与分期明显相关。结论" 血TC、LDL-C、RC、HCY水平与PD发病相关，TC、LDL-C、RC水平是PD的保护因素，HCY是PD的危险因素。RC水平与PD严重程度呈负相关，RC、TC水平与PD分期呈负相关。

    关键词：帕金森病；血脂；残余胆固醇；血同型半胱氨酸；血尿酸

    中图分类号：R512.91" " " " " " " " " " " " "文献标识码：A" " " " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2025.05.017

    文章编号：1006-1959(2025)05-0108-05

    Abstract： Objective" To investigate the correlation between the levels of blood lipid， uric acid (UA) and homocysteine (Hcy) and the severity of Parkinson′s disease (PD). Methods" A total of 92 PD patients who were admitted to the Department of Neurology of our hospital from January 2021 to August 2024 were selected as PD group. A total of 92 healthy subjects in the physical examination center during the same period were selected as the healthy control (HC) group. The levels of total cholesterol (TC) ......