摘要：乳腺癌是女性中最常见的恶性肿瘤，是一种全身性疾病，是体内外多种因素共同作用的结果。人体中D-二聚体水平与乳腺癌有着密切的联系。D-二聚体水平与乳腺癌患者的区域淋巴结转移、肿瘤大小、年龄、月经状态密切相关。同时，与乳腺癌患者的病理指标如雌激素受体(ER)、孕激素受体(PR)、Ki-67、人表皮生长因子受体-2(HER-2)、p53、分子分型、病理分级有着一定的相关性，但是仍存在诸多的争议。D-二聚体作为凝血系统中一种能够检测的较为敏感且简单的生物指标，对乳腺癌临床工作开展能够提供一定的参考价值。本研究通过综述D-二聚体与乳腺癌临床病理特征关系的相关报道，以期为两者之间的关系提供新的研究方向。

    关键词：D-二聚体；乳腺癌；临床特征；病理指标

    中图分类号：R737.9" " " " " " " " " " " " " 文献标识码：A" " " " " " " " " " " " DOI：10.3969/j.issn.1006-1959.2025.05.034

    文章编号：1006-1959(2025)05-0187-06

    Abstract： Breast cancer is the most common malignant tumor in women， and it is also a systemic disease， which is the result of a variety of factors in vivo and in vitro. The level of D-dimer in human body is closely related to breast cancer， and its level is closely related to regional lymph node metastasis， tumor size， age and menstrual status of breast cancer patients. At the same time， it has a certain correlation with the pathological indicators such as estrogen receptor (ER)， progesterone receptor (PR)， Ki-67， human epidermal growth factor receptor-2 (HER-2)， p53， molecular typing and pathological grading ......