基于孟德尔随机化分析探讨骨关节炎与2型糖尿病的关联

http://www.100md.com 2025年6月24日医学信息 2025年第7期

遗传变异,因果关系

    AssociationBetween Osteoarthritisand Type2DiabetesMellitus Based on Mendelian Randomization Analysis

    MALixin1，XUZujian12

    (1.CollegeofItegrativeineseandWesternMedicine，outhwestedicalUniversity，Luzou646oo，ichuanCina；

    .DepartmentofropdsdJots，latedspialoditoalseiceouwestcalUih

    ，Sichuan， China)

    Abstract：Oel associationstudy(GW)sumarydatafrodfrenteseachinstutiossuchsrcOGENUKiobank)wersedOusedssure factorandTDMwasusedasanutcomevariableMultileMendelianrandomzation(M)analysisetods，includingversevariaceeihtin (VW)weida TDMrisk.ResultshrsusofIVWowdatOAsociatedigsofD(OR9%Co0O valueofMR-Egdosisttiatfgeegessodattsaedidottal polytropy

.Cochrane'sQ test showed no heterogeneity in IVs

.Sensitivity analysis showed that the causal effect was stable. Conclusion MR analysis support that OA is associated with an increased risk of T2DM. ......

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