基于网络药理学探讨黄芩治疗肺癌的有效成分和作用机制
Abstract：ObjeciveToanalyethepotentialtargetsandmechansmofadixsuteliaeinthetreatmentoflungcancerbasedoetwork pharacologetodshecieomponntsndargegnesofdiutellieerebandPndeungnced wereobtainedyeCardndOaabasndeintersectioeesofttoeretakenTePetwkdagaofttio geneswasobtaiedusingteStringdatabaseandthGOanalysisndKEGGerichmentanalysisoftekeyargetgeneswereperfodusingthe R (2 softwareustelcagsultsotalofouds4opodgetsd4ngceadetd Therewere55odesnd8eodesinproteininteractionetworkGOfucioalrichentaalysisaied93ologicalprod KEGGpathwayeichentaalysisbained37igalingpathwayseainactivecomponentssuchsogoninicaleincacetind β 1 siosteroleredededUGAKa mainlyncludeEosallellgedialisiis radix scutellariae，such as wogonin，baicalein，acacetin and β -sitosterol，mayact onAKT1，IL6，HIF1A，JUN，CCND1，ESR1，PTGS2，VEGFAand othertargetstougAGERAGE，I7poptosisallcellungancer5ndhersigaigpathwandnplaeolefd scutellariae inanti-lung cancer，showing thecharacteristicsof multi-component，multi-targetand multi-pathway.KeyWords：Network pharmacology；Radix scutellariae；Lung cancer；Active component
肺癌(lungcancer)作为全球范围内发病率和致死率均居于首位的恶性肿瘤类型 ......
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