基于生物信息学探索GAS2L3在肝癌中的表达与意义

http://www.100md.com 2025年6月24日医学信息 2025年第7期

     Abstract：OjectiveTexloetexpressoofSiivrancnditsotetialhanmMeoseexpresioicf GAS2L3innorallivertisueandlivercancertisuewasdetectedbyR-PCR，andverfiedbyCancerGenomeAtlas(TCGA)databaseand integratedgeeexpressoabas(GEO)OCressaateeccacfiagossoflieaceKplae metodUddles liverancer.GEOdatabaseasusedtoverifythesurvivalrelatioship.AcolumngaphasconstructedusingGAS2L3andlinicalvariablesTe corelatonbetweenGAS2L3andimmuneinfiltratonwasanalyzedbyusingESTMATE，CIBERSORandTMERdatabasesResultsAfter bioinfortialsdalioitfdatprsfiicssaal tisuesnditspsasealaltolcaladldingofleaeUort diagnosisoflivercancryG3wasO27AtthmeeurvivalalyissodtatpatientsithgSL3dorrogod singleadultactorCOXalyissotathiglexpredGL3ouldesdepedentomarerfiveraerIdio GO，KEGGandGEicetntsgstedhatightodincearisiodeotellclenly enricdilliedexpsei immuneinflraociisediveedlaiinro withlowsurvivalatendiuneifiatioGLcaneusedsotetaomakendiuothaargetfoeacerois

    Keywords：Liver cancer；GAS2L3；Bioinformatics；TCGAdatabase；GEO database

    肝癌(livercancer)是全球第六大常见的癌症和第四大癌症死亡原因[1。该疾病预后较差，只有 5 % 210 % 的早期患者适合手术治疗2。目前，关于该疾病发生、发展的分子机制尚不清楚，且缺乏肿瘤类型或者疾病阶段的特异性标志物 ......

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